BACKGROUND The aim of the present study was to enhance a topical delivery of hirsutenone (HST), a naturally occuring immunomodulator, employing Tat peptide-admixed elastic liposomes (EL/T). METHODS HST-loaded EL, consisting of phosphatidylcholine and Tween 80 (85:15 w/w%), were prepared using thin film hydration method. By adding Tat peptide to EL (0.16 w/w%), EL/T were formulated. The in vit...

This study reports on the relationship between evaluative learning (EL) and attentional preference in children with varying degrees of anxiety, as measured by the Multidimensional Anxiety Scale for Children, and varying degrees of parental anxiety, as measured by scores on the Beck Anxiety Inventory (BAI). In the first experiment, 3 age groups (7-8, 10-11 and adults with mean age 26.8 years) we...

[Purpose] Among the non-pharmacological interventions for dementia, spaced retrieval training (SRT) is a good method for rehabilitating cognition. The purpose of this study was to examine effects of SRT with errorless learning (EL) in the rehabilitation of patients with dementia. [Subjects and Methods] Twenty-nine participants with vascular dementia (VD) and Alzheimer's disease (AD) participate...

Resumen. Actualmente no existe un método ampliamente aceptado para la captura de requisitos de interacción. El dibujo de bocetos de la interfaz de usuario va cobrando poco a poco un papel importante dentro de este ámbito. Es necesario el desarrollo de herramientas que permitan dibujar estos bocetos en formato digital. Además, siguiendo el paradigma MDA, el esfuerzo aplicado en la captura de req...

The 1997-98 El Nino was, by some measures, the strongest on record, with major climatic impacts felt around the world. A newly completed tropical Pacific atmosphere-ocean observing system documented this El Nino from its rapid onset to its sudden demise in greater detail than was ever before possible. The unprecedented measurements challenge existing theories about El Nino-related climate swing...

The Cox model with time-dependent coefficients has been studied by a number of authors recently. In this paper, we develop empirical likelihood (EL) pointwise confidence regions for the time-dependent regression coefficients via local partial likelihood smoothing. The EL simultaneous confidence bands for a linear combination of the coefficients are also derived based on the strong approximation...

In many studies of health economics, we are interested in the expected total cost over a certain period for a patient with given characteristics. Problems can arise if cost estimation models do not account for distributional aspects of costs. Two such problems are (1) the skewed nature of the data, and (2) censored observations. In this paper we propose an empirical likelihood (EL) method for c...

Resumen. Con el creciente interés en el paradigma de las arquitecturas orientadas a modelos (Model-Driven Architecture), los modelos conceptuales son la columna vertebral del proceso de desarrollo de software. En este trabajo se presenta un marco de evaluación de usabilidad en el contexto de la tecnología OlivaNova Model Execution, la implementación industrial del método de producción automátic...

Gate degradation in high electron mobility transistors (HEMTs) under OFF-state stress results from the high electric field near the gate edge. We investigate the evolution of this field over time in AlGaN/ GaN HEMTs upon OFF-state stress using a combination of electroluminescence (EL) microscopy and spectroscopy. EL analysis suggests that the electric field at the sites of generated surface def...

Recent advances in the econometric modelling of count data have often been based on the generalized method of moments (GMM). However, the two-step GMM procedure may perform poorly in small samples, and several empirical likelihood-based estimators have been suggested alternatively. In this paper I discuss empirical likelihood (EL) estimation for count data models with endogenous regressors. I c...