Aging skin is an issue of concern to many patients. In this review aging and photoaging are defined, mechanisms which underlie these processes explored, and available treatment options discussed.

Corneal buttons of two patients with lattice corneal dystrophy were studied by light and electron microscopy. They showed elastotic degeneration within the amyloid deposits. The amyloid deposits displayed characteristic staining; the elastotic material (elastin) within the deposits stained positive with Verhoeff-van Gieson and Movat pentachrome stains and showed autofluorescence. The characteri...

Heart failure in young subjects, when unaccompanied by signs of congenital abnormality or rheumatic disease, can pose a diagnostic problem that may remain unsolved even after careful pathological study. A proportion of such cases in infancy is caused by endocardial fibro-elastosis (Prior and Wyatt, 1950; Dennis et al., 1953), and it has even been suggested that this is one of the commonest type...

Endocardial fibro-elastosis is no rare finding in infants and young children up to two years of age, and as a rule it leads rapidly to death. Panke and Rottino (1955) found that of 129 cases described 78 per cent had died below the age of twelve months. Its frequency is much less in older children and adults (Smith and Furth, 1943; Hughes and Smith, 1953; White and Fennell, 1954; Thomas et al.,...

ransepidermal elimination is a disorder in which T dermal stimuli profoundly effect the behavior and structure of the overlying epidermis. Briefly, there are two categories of disorders: the first are primary dermatoses and consist of elastosis perforans serpiginosa and reactive perforating collagenosis; the second group originates from alterations of dermal constituents in preexisting disorder...

Skin involvement in chronic renal failure is characterized by a multitude of different aspects. Often pruritus, xerosis cutis, hyperpigmentations, and actinic elastosis occur. These symptoms tend to alter and are aggravated relatively quickly when chronic renal insufficiency leads to compulsory dialysis treatment. The following article reviews the clinical and histological aspect of cutaneous a...

The photoaging process of facial skin is investigated by use of multiphoton fluorescence and second-harmonic generation (SHG) microscopy. We obtain the autofluorescence (AF) and SHG images of the superficial dermis from the facial skin of three patients aged 20, 40, and 70 years. The results show that areas of AF increase with age, whereas areas of SHG decrease with age. The results are consist...

Figure 1. Small cysts and open comedones in an agminate arrangement post shave biopsy. Figure 2. Photomicrograph of skin containing two mildly inflamed comedonal cysts embedded in a dermis with evidence of severe solar damage (4x). Figure 3. Photomicrograph of the surrounding dermis demonstrating severe nodular solar elastosis indicating significant prolonged sun exposure (20x). Abstract The de...