- pseudohypoaldosteronism (p'ha) is referred to a state of endorgan unresponsiveness to aldosterone. in this article a 12 day - old mule newborn is presented with hyponatremia, hyperkalemia and metabolic acidosis. aldosterone level and plasma renin activity were high. mineralocorticoids had no therapeutic effect, hut normal saline infusion improved electrolyte imbalance. salt-rich diet was succ...

BACKGROUND Fluid and electrolyte balance is a key concept to understand for maintaining homeostasis, and for a successful treatment of many metabolic disorders. There are various regulating mechanisms for the equilibrium of electrolytes in organisms. Disorders of these mechanisms result in electrolyte imbalances that may be life-threatening clinical conditions. In this study we defined the elec...

The purpose of this study was to assess the possibility of prognosis of oral squamous cell carcinoma by microsatellite blood assay. Altered microsatellite DNA in the blood of cancer patients may provide a novel method for tumor detection. DNA from normal and tumor tissues and serum obtained at two time-points (preoperatively and postoperatively) in 20 patients with oral squamous cell carcinoma ...

A common single nucleotide polymorphism (SNP), rs6983267, at 8q24.21 has recently been shown to associate with colorectal cancer (CRC). Three independent SNP association studies showed that rs6983267 contributes to CRC with odds ratios (OR) of 1.17 to 1.22. Here, we genotyped a population-based series of 1,042 patients with CRC and 1,012 healthy controls for rs6983267 and determined the contrib...

Fluid and electrolyte disorders are very common in critically ill patients. There are some circumstances in which a patient is placed in intensive care for the management of a specific electrolyte disturbance such as hyponatremia or hyperkalemia. The development of electrolyte disturbances among critically ill patients is also common due to breakdown of homeostatic mechanisms that prevent the d...

Allelic imbalance (AI) encompassing the apoptotic protease-activating factor 1 (APAF-1) locus (12q22-23) is found frequently in metastatic melanoma. Circulating DNA with AI on 12q22-23 in serum was evaluated as a surrogate marker to predict biochemotherapy (BC) treatment response in melanoma patients. Sera were collected from 49 American Joint Committee on Cancer stage IV melanoma patients trea...

In recent years the clinical significance of the electrolyte balance of the blood has become increasingly realized, and was the subject of a leader in the Lancet. This has also been stressed by other workers (Baumann, 1952; Black, 1953; Graham, 1954; Wynn and Rob, 1954). The following investigation was carried out with a view to finding whether a rapid screening test could be of practical clini...