This article explores the novel gold nanoparticle-enhanced photodynamic therapy of methylene blue against recalcitrant pathogenic Candida albicans biofilm. Physiochemical (X-ray diffraction, ultraviolet-visible absorption, photon cross-correlation, FTIR, and fluorescence spectroscopy) and electron microscopy techniques were used to characterize gold nanoparticles as well as gold nanoparticle-me...

Purpose: To investigate conflicting results demonstrating higher cell-kill by irradiated high atomic number (Z) material, gold (Au) in tumor compared to Monte Carlo (MC) modeled enhancement in radiation dose deposition, and to compare the difference between radiosensitizing effects of gold and platinum. Methods and Materials: Since a majority of cell kill due to radiation is mediated by free ra...

We report a new self-assembly pathway that leads to supported and hierarchically organized gold nanoparticle mesostructure arrays on solid substrates such as glass slide, thermal oxide, photopolymer film, and mica. Using the nanoparticle micelle as a building block, hierarchical gold nanoparticle mesostructure arrays were prepared by a hydrothermal nucleation and growth process through self-ass...

Abstract The estimate of the total electron yield is fundamental for our understanding test-mass charging associated with cosmic rays in Laser Interferometer Space Antenna (LISA) Pathfinder mission and forthcoming gravitational wave observatory LISA. To unveil role low energy electrons this process owing to galactic solar energetic particle events, work we study interaction keV sub-keV a gold s...

background: field matching problems in abutting electron fields can be managed by using spoilers. objective: the aim of this study was to design a monte carlo framework for the assessment of spoiler application in abutting electron fields. methods: a siemens primus treatment head was simulated for a 5 mev electron beam using beamnrc and dosxyznrc, egsnrc user codes. validation of beam model was...

In this study, we quantify the relative damage enhancement due to the presence of gold nanoparticles (GNP) in vitro in a clinical 6 MV beam for various delivery parameters and depths. It is expected that depths and delivery modes that produce a larger proportions of low-energy photons will have a larger effect on the cell samples containing GNP. HeLa cells with and without 50 nm GNP were irradi...

Radio-sensitization with gold nanoparticles (GNPs) is a relatively recent advancement of radiotherapy that determined to increase radiation in the target tumor region. Monte Carlo (MC) simulation well-known method has gained popularity by assisting determining effective dose various tumors. Assessing concentration particles during proton therapy can provide key evaluating efficiency performed t...

Background: Radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools and tissue-like developed to date. Among the special features of this type of dosimeters, is be doped with other elements or chemicals which made them appropriate for investigating of dose enhancement with contrast agents, by high atomic number. Material and Methods: In this study...

PURPOSE Since the first publications on intensity modulated radiation therapy (IMRT) in the early 1980s almost all efforts have been focused on fairly time consuming dynamic or segmental multileaf collimation. With narrow fast scanned photon beams, the flexibility and accuracy in beam shaping increases, not least in combination with fast penumbra trimming multileaf collimators. Previously, expe...