DNA shape variation and the associated variation in minor groove electrostatic potential are widely exploited by proteins for DNA recognition. Here we show that the hydroxyl radical cleavage pattern is a quantitative measure of DNA backbone solvent accessibility, minor groove width, and minor groove electrostatic potential, at single nucleotide resolution. We introduce maps of DNA shape and ele...

Telecommunications providers expect products to perform reliably during operation in the field. Achieving the expected hardware reliability is due to an amalgamation of multiple factors. A significant contribution to reliable performance results from the incorporation of specific materials, which are very corrosion resistant and electrostatic discharge (ESD) safe during the design and manufactu...

In this paper we propose a nonlinear elasticity model of macromolecular conformational change (deformation) induced by electrostatic forces generated by an implicit solvation model. The Poisson-Boltzmann equation for the electrostatic potential is analyzed in a domain varying with the elastic deformation of molecules, and a new continuous model of the electrostatic forces is developed to ensure...