α-Methylacyl-CoA racemase (AMACR; P504S) catalyses a key step in the degradation of branched-chain fatty acids and is important for the pharmacological activation of Ibuprofen and related drugs. Levels of AMACR are increased in prostate and other cancers, and it is a drug target. Development of AMACR as a drug target is hampered by lack of a convenient assay. AMACR irreversibly catalyses the el...

background: this study aims to investigate the patterns of bioaccumulation and depuration of copper in the selected kidney and liver of capoeta fusca. methods: the fish were collected between september and november 2010 from a qanat in birjand. they were exposed to two types treatments with copper (0.25 and 0.75 mg/l) for a period of 41 days. the fish under study were exposed to the above-menti...

since it was first diagnosed in 1914 in marrakesh, schistosomiasis has been a public health problem in morocco for decades. a national control program launched in 1982 has led to a considerable reduction in the incidence and morbidity associated with the disease. consequently, the program has shifted from disease control to an elimination process launched in 1994. this process aimed to eliminat...

background: baits have become popular and effective formulations against urban insect pests. compared with re­sidual sprays toxic gel baits are used more and more frequently to control urban cockroach populations. the aim of this study was to investigate the usage of two commercially available fipronil and imidacloprid gel bait formulations against blattella germanica field infested in iran. me...

conclusions affordable new hcv treatment regimens are available in iran, providing an opportunity for hcv elimination. recommendations provided in this current national guideline can facilitate evidence-based management of hcv infection. results pegylated interferon alpha (pegifn), ribavirin (rbv), sofosbuvir (sof), ledipasvir (ldv) and daclatasvir (dcv) are currently available in iran. pre-tre...

A widely used class of algorithms for computing tree decompositions of graphs are heuristics that compute an elimination order, i.e., a permutation of the vertex set. In this paper, we propose to turbocharge these heuristics. For a target treewidth k, suppose the heuristic has already computed a partial elimination order of width at most k, but extending it by one more vertex exceeds the target...

Measles was eliminated in the Americas in 2002 by a combination of routine immunizations and supplementary immunization activities. Recent outbreaks underscore the importance of reconsidering vaccine policy in order to maintain elimination. We constructed an age-structured dynamical model for the distribution of immunity in a population with routine immunization and without disease, and analyse...

Recently, technology has become available to generate soluble T-cell receptors (sTCRs) that contain the antigen recognition part. In contrast to antibodies, sTCRs recognize intracellular in addition to extracellular epitopes, potentially increasing the number of applications as reagents for target detection and immunotherapy. Moreover, recent data show that they can be used for identification o...

In 1997, the 22 countries in the World Health Organization (WHO) Eastern Mediterranean Region (EMR) adopted a goal of measles elimination by 2010. To achieve this goal, the WHO Regional Office for the Eastern Mediterranean Region (EMRO) developed a four-pronged strategy: 1) achieve ≥ 95% vaccination coverage of children with the first dose of measles-containing vaccine (MCV1) in every district ...