The health-related effects of interactions between reactive oxygen species (ROS) and dietary antioxidants and the consequences of dietary antioxidant supplementation on human health are by no means clear. Although ROS, normal byproducts of aerobic metabolism, are essential for various defense mechanisms in most cells, they can also cause oxidative damage to DNA, proteins, and lipids, resulting ...

The realization that reactive oxygen species and oxidative stress play an important role in the etiology and progression of major human degenerative diseases has triggered enormous and worldwide interest in endogenous and exogenous antioxidants. The 1990’s have seen the explosion of interest in antioxidants. The article reviews free radical chemistry, antioxidant systems & their role in human d...

INTRODUCTION Antioxidants protect living organisms from damage caused by uncontrolled production of reactive oxygen species (ROS) and the concomitant lipid peroxidation, protein damage and DNA strand breaking. Current interest is focused on the potential role of antioxidants and antioxidant enzymes in the treatment and prevention of atherosclerosis, heart failure, neurodegenerative disorders, a...

SEVERAL FINDINGS SUGGEST THAT oxidative stress may play an important role in the pathogenesis of Alzheimer disease. First, the brains of patients with Alzheimer disease contain lesions that are typically associated with exposure to free radicals. In addition, oxidative stress in brains of Alzheimer patients is indicated by elevated cerebral levels of endogenous antioxidants that scavenge free r...

Environmental pollution has increased over the past few decades, posing serious risks to all biological systems, including poultry sector. Oxidative stress in chickens caused by dietary, environmental, and pathological variables influences how well perform as quality of meat eggs. Lead (Pb) cadmium (Cd) are two examples heavy metals that harmful for chicken health. They can cause oxidative incr...

the increasing susceptibility of broiler chickens to ascites syndrome has coincided with a continuing genetic and nutritional improvement in their feed efficiency and growth rate. ascites is multifactorial and interactions between environmental and endogenous factors play a particularly important role. the selection of fast growing broilers for high feed efficiency, which is characterized by hy...

BACKGROUND Whereas several epidemiological studies suggest that low dietary intake of vitamins C and E is linked to increased hip fracture in smokers and antioxidants (dietary and endogenous) are reduced in elderly osteoporotic women, none has demonstrated an effect of supplemental antioxidants on bone turnover. METHODS In an observational study of 533 randomly selected women, we investigated...

Polyunsaturated fatty acids and antioxidants are important mediators in the central nervous system. Lipid derivatives may control the production of proinflammatory agents and regulate NF-κB activity, microglial activation, and fatty acid oxidation; on the other hand, antioxidants, such as glutathione and ascorbate, have been shown to signal through transmitter receptors and protect against acut...

Polyunsaturated fatty acids (PUFAs) and antioxidants are important mediators in the 14 central nervous system (CNS). Lipid derivatives may be used to generate endocannabinoids or 15 prostanoids derived from arachidonic acid, which attenuates excitotoxicity in quadripartite 16 synapses with a focus in astrocytes and microglia; on the other hand, antioxidants, such as 17 glutathione (GSH) and asc...