Background: Because implantation failure is more frequent, many methods have been suggested to improve the implantation; however, their results have been inconsistent. One of the most hopeful methods is local endometrial injury. To explore the possibility that local injury of the endometrium increases the incidence of implantation and pregnancy rate in the subsequent IVF cycle in patients havin...

OBJECTIVE To implement the procedure of endometrial biopsy in a case of severe Asherman syndrome as a possible treatment to increase uterine receptivity. DESIGN Case report. SETTING IVF Unit, Kaplan Medical Center, Rehovot, Israel. PATIENT(S) A 29-year-old patient with severe Asherman syndrome, who underwent six operative hysteroscopies combined with hormonal treatment, and no functional ...

BACKGROUND Endometriosis can cause dysmenorrhea and infertility. Its pathogenesis has not yet been clarified and its treatment continues to pose enormous challenges. The protein tyrosine phosphatase (PTEN) gene is a tumor suppressor gene. The aim of this study was to investigate the role and significance of PTEN protein in the occurrence, development, and treatment of endometriosis through chan...

BACKGROUND Implantation remains a limiting step in IVF/ICSI. Endometrial injury isa promising procedure aiming at improving the implantation and pregnancy rates after IVF/ICSI. OBJECTIVE The aim of this study was to evaluate the effect of endometrial injury induced in precedingcycle on IVF/ICSI outcome. MATERIALS AND METHODS Four hundred patients undergoing their first IVF/ICSI cycle in two...

intrauterine insemination (iui) has been widely used for the treatment of infertility. several prognostic factors for iui outcome have been proposed, including the endometrial thickness and follicle numbers, etiology and duration of infertility and morphology, type and motility of sperms. a total of 463 iui cycles in which clomiphene citrate and/or human menopausal gonadotrophin (hmg) were used...

OBJECTIVE To evaluate the clinical response and endometrial morphology during the implantation window on ovarian hyperstimulation with the aromatase inhibitor letrozole in infertile ovulatory women. DESIGN Prospective trial in infertile patients. SETTING Tertiary care hospital. PATIENT(S) Eight ovulatory infertile patient candidates for ovarian superovulation. INTERVENTION(S) Subjects w...

High rates of aerobic glycolysis represent a key mechanism by which endometrial cancer cells consume glucose as its primary energy source. The up-regulated glycolytic pathway is a common therapeutic target whose inhibition has implications for anti-tumor activity in cancer cells. The present study was aimed at evaluating the potential of a novel lactate dehydrogenase (LDH) inhibitor, Galloflavi...

Mechanical endometrial injury (biopsy/scratch or hysteroscopy) in the cycle preceding ovarian stimulation for IVF has been proposed to improve implantation in women with unexplained recurrent implantation failure (RIF). This is a systematic review and meta-analysis of studies comparing the efficacy of endometrial injury versus no intervention in women with RIF undergoing IVF. All controlled stu...

background: endometriosis is the presence of endometrial glandular and stromal cells outside of the uterine cavity. our previous study showed that in vitro culture of human endometrial tissue in a three-dimensional (3d) fibrin matrix could mimic the early stages of endometriosis with invasion gland and stroma formation and sprouting of new vessels. objective: the objective of the present study ...

BACKGROUND Toll-like receptors (TLRs) play an essential role in the innate immune system by initiating and directing immune response to pathogens. TLRs are expressed in the human endometrium and their regulation might be crucial for the pathogenesis of endometrial diseases. METHODS TLR3 and TLR4 expression was investigated during the menstrual cycle and in postmenopausal endometrium consideri...