نتایج جستجو برای: endophenotypes
تعداد نتایج: 1086 فیلتر نتایج به سال:
INTRODUCTION As endophenotypes bridge the gap between genetics and phenotypic disease expression, identifying reliable markers is important for fostering understanding of pathophysiology. The present aim was to conduct current meta-analyses of 3 key auditory event-related potential (ERP) components that have been held as potential endophenotypes for schizophrenia: P50, P300 amplitude and latenc...
Background There is increasing evidence showing that induced pluripotent stem cells (iPSC)-derived brain recapitulate disease-relevant processes in patients with Alzheimer’s disease (AD). However, it remains unclear to what extent iPSC-derived neurons treated amyloid-β (Aβ) reflect patient Aβ burden and other endophenotypes as determined by changes protein expression. Method To investigate this...
Borderline personality disorder (BPD) is a genetically influenced psychiatric illness with disruptions in neural systems supporting cognition and emotion regulation. Volumetric decreases of the hippocampus and amygdala may characterize BPD and serve as putative endophenotypes for the illness. The purpose of the present study was to evaluate whether the magnitude of these volume reductions and t...
OBJECTIVE The understanding of complex heritable psychiatric disorders such as schizophrenia could be clarified by examining endophenotypes within genetically isolated populations, such as the one found in the Central Valley of Costa Rica. The reduction of familial variability within a sample could allow the relationship between the cognitive and symptomatic manifestations of the illness and th...
The aim of this study was to identify promising endophenotypes for intelligence in children and adolescents for future genetic studies in cognitive development. Based on the available set of endophenotypes for intelligence in adults, cognitive tasks were chosen covering the domains of working memory, processing speed, and selective attention. This set of tasks was assessed in a test–retest desi...
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