Fabienne Foufelle, Sophie Lotersztajn, Paul A. Insel, and Eric Chevet Inserm, UMR-S 1138, Université Pierre et Marie Curie, Centre de Recherches des Cordeliers, Paris, France; Inserm, UMR-S 1149, Université Paris Diderot, Centre de Recherche sur l’Inflammation, Paris, France; Departments of Pharmacology and Medicine, University of California-San Diego, La Jolla, California; and Inserm, U1053, U...

Cancer cells survive and grow despite various advanced anti-cancer therapy. To overcome this antineoplastic resistance, adjuvant therapy is often required to prevent cancer cells' immunoescape capacity. Established tumors build a stressful hostile microenvironment in order escape protective innate adaptive immune responses. Specific conditions factors within tumors, including hypoxia, nutrient ...

Telomerase contributes to cell proliferation and survival through both telomere-dependent and telomere-independent mechanisms. In this report, we discovered that endoplasmic reticulum (ER) stress transiently activates the catalytic components of telomerase (TERT) expression in human cancer cell lines and murine primary neural cells. Importantly, we show that depletion of hTERT sensitizes cells ...

The endoplasmic reticulum (ER) is a central organelle entrusted with lipid synthesis, protein folding and protein maturation. It is endowed with a quality control system that facilitates the recognition and targeting of aberrant proteins for degradation. When the capacity of this quality control system is exceeded, a stress response (ER stress) is switched on. Prolonged stress leads to apoptosi...

The endoplasmic reticulum (ER) is the principal organelle responsible for multiple cellular functions including protein folding and maturation and the maintenance of cellular homeostasis. ER stress is activated by a variety of factors and triggers the unfolded protein response (UPR), which restores homeostasis or activates cell death. Multiple studies have clarified the link between ER stress a...

PURPOSE Rac3 plays an important role in regulating tumorigenesis. Autophagy plays a vital role in tumorigenesis and tumor progression. The relationship between the two remains unclear. The objective of the present study was to determine the specific molecular mechanism of intracellular Rac3 in regulating autophagy and reveal the relationship between tumor cell autophagy and apoptosis. METHODS...

Abstract The cellular pool of RNA is immensely diverse and complex. During their biosynthesis, molecules undergo a vast number co- posttranscriptional processing modification steps. A unique example the non-conventional splicing RNAs. This protein-catalysed mechanism an essential step during tRNA maturation main mode endoplasmic reticulum (ER) stress signalling. Here, I discuss roles catalytic ...

Cellular homeostasis is supported by a symphonic balancing act involving protein synthesis, folding, modification, trafficking and degradation. In eukaryotic cells the endoplasmic reticulum (ER) is a specialized organelle that is the central site of synthesis and folding of secretory, membrane and a number of organelletargeted proteins. Correct folding and post-translational modifications of th...

Endoplasmic reticulum (ER) stress due to the presence of misfolded or unfolded proteins in the ER invokes a fundamental biological response, termed the unfolded protein response (UPR). The UPR is orchestrated by three main proximal effectors, of which the IRE1/XBP1 pathway represents the evolutionarily most conserved one. Due to its high secretory burden, the intestinal epithelium is highly sus...