although the etiology of varicose veins remains unknown, recent studies have focused on endothelial cell integrity and function because the endothelium regulates vessel tone and synthesizes many pro- and anti-inflammatory factors. the aim of this study was to investigate the evidence involving the endothelium in the development of varicose vein disease. in addition, tissue remodeling was invest...

objective: diabetes is an important risk factor for cardiovascular events. the great percent of morbidity in patients with diabetes is due to endothelial dysfunction. the present study investigated the effects of hydroalcholic extract of nigella sativa (n. sativa)  on contractile and dilatation response of isolated aorta in streptozotocin (stz)-induced diabetic rat. materials and methods: rats ...

background & aims of the study: oxidative stress increases platelet-derived growth factor (pdgf) gene expression in endothelial cells that contributes to vascular dysfunction and atherosclerosis. oxidative stress generates by dys-regulated redox balance between ros producing systems and antioxidant systems. also, curcumin (cur) as a main part of turmeric has anti- inflammatory, antioxidant, ant...

introduction: angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. cardiovascular endothelial factors are involved in diseases and vascular regulation.  stachys lavandulifolia belongs to the laminacea family and its hydroalcoholic extract is used as a traditional treatment to reduce pain and inflammation. the present study was conducted to ex...

background: myocardial infarction is the main cause of death worldwide. angiogenesis, a promising new therapy for the treatment of diffuse coronary artery disease, shows a poor response to conventional revascularization techniques. this study focused on improving myocardial function using endothelial cells (ecs) and mesenchymal stem cells (mscs) in a sheep animal model. methods: acute myocardia...

conclusions combination of creatine monohydrate and exercise attenuated inflammation and endothelial dysfunction markers among heart failure patients. patients and methods one hundred patients were prospectively randomized into two groups: intervention group which received 5 grams/day creatine monohydrate and exercised for 8 weeks; and control group which did not receive any interventions. inte...

vascular endothelial growth factor (vegf-a) is one of the most important regulatory factors in pathological and physiological angiogenesis. alternative splicing is a complicated molecular process in vegf-a gene expression which adds complexity to vegf-a biology. among all vegf-a exons, alternative splicing of exon 8 is the key determinant of isoform switching from pro-angiogenic vegf-xxx to ant...

introduction: pulsed dye laser (pdl) is an important treatment for superficial infantile hemangioma, but few studies report on its cellular mechanism. the aim of this study was to evaluate alterations of serum vascular endothelial growth factor (vegf) level in infantile hemangioma (ih) patients after laser treatment and effects of pdl irradiation on human umbilical vein endothelial cells (huvec...

We found that resistance and endurance exercise modalities lead to different endothelial function responses after a single bout of exercise. Endothelial increased an acute exercise, whereas it decreased Four weeks chronic training did not affect the response.