objective: envenomation by heamotoxic snakes constituted a critical health occurrence in the world. bleeding is the most sever consequence following snake bite with viperid and crothalid snakes. it is believed that the degradation of vascular membrane caused hemorrhage; in contrast, some suggested that direct cytotoxicity has role in endothelial cell disturbances. this study was to evaluate the...

introduction: angiogenesis play an important role in many physiological processes (embryonic growth, tissue repair, etc) and also in pathological ones (diabetes, retinopathy, arthritis, tumor growth, etc). evaluation of endothelial cell growth and finally new vessel development in vivo is a complex and often difficult task. materials & methods: to address this issue an in vitro experimental ang...

purpose: to evaluate the corneal endothelial cell density and polymegathism one year after laser assisted keratomileusis using mitomycin c. methods: one hundred and three eyes from 52 patients who underwent laser assisted sub-epithelial keratomileusis using mitomycin c 0.02% for 30 seconds entered this study. corneal endothelial cells were evaluated using specular microscopy before and one year...

AIM: To investigate the expression and effect of histone deacetylase 7 (HDAC7) in human retinal microvascular endothelial cells (HRMECs) under high glucose condition related mechanism, HDAC7 tissue diabetic rats. METHODS: The HRMECs from normal or rats were detected with immunohistochemistry Western blot. LV-shHDAC7 used to study on cell activities. Cell count kit-8 (CCK-8), 5-ethynyl-2’-deoxyu...

OBJECTIVE To investigate how precise Descemet stripping works in posterior lamellar keratoplasty (Descemet stripping automated endothelial keratoplasty [DSAEK]) for the treatment of corneal endothelial disorders. METHODS In a prospective, single-center, nonrandomized consecutive series, 20 Descemet membrane specimens obtained after Descemet stripping in DSAEK using a Price hook were examined ...

BACKGROUND The nature of chronic endothelial cell loss in homologous corneal grafts is still unclear. Possible causes are cell migration to the recipient bed and chronic subclinical immune reaction. OBJECTIVES To compare endothelial cell loss after autologous rotational keratoplasty and homologous keratoplasty and present the clinical outcome of patients after rotational keratoplasty. METHO...

recent evidences suggest that multiple myeloma phenotypes (mmps) are involved in the infiltration of multiple myeloma-affected marrow foci. in this study, the effects of arsenic trioxide on the invasive and angiogenic phenotypes of multiple myeloma (mm) cell line were assessed on a dose-response and time-course basis. multiple myeloma cell line, karpas 707, was treated with step-wise elevated c...