The ability of selenium to protect cultured human coronary artery endothelial cells (HCAEC), human umbilical vein endothelial cells (HUVEC) and bovine aortic endothelial cells (BAEC) from oxidative damage induced by 100 microM t-butyl hydroperoxide (t-BuOOH) was compared. Preincubation of human endothelial cells for 24 h with sodium selenite at concentrations as low as 5 nM provided significant...

occur postoperatively) have recently been implicated as possible markers of corneal endothelial cell damage. We have examined this phenomenon in vivo with the slit-lamp and specular microscope. We recognised three types of linear form and, in contradiction of other observers, found that each was always coincident with a wrinkle in Descemet's membrane. Moreover, we were able to demonstrate only ...

Previous studies have shown that approximately 40 per cent of the corneal endothelial cells can be lost at the time of intraocular lens insertion. Momentary contact between the methacrylate surface and the endothelial cells causes an adhesion between these surfaces and results in extensive cell damage upon separation of the surfaces. This type of damage appears to be due to a biophysical intera...

'Snailtracks' (grey-white streaks and patches on the posterior corneal surface which occur postoperatively) have recently been implicated as possible markers of corneal endothelial cell damage. We have examined this phenomenon in vivo with the slit-lamp and specular microscope. We recognised three types of linear form and, in contradiction of other observers, found that each was always coincide...

Interactions of granulocytes with vascular endothelial cells, a prominent feature of the inflammatory response, can result in endothelial damage. Hydrogen peroxide, released during the respiratory burst associated with granulocyte activation, has been implicated in causing lethal damage on the basis of experiments that demonstrated catalase-inhibitable release of 5~Cr from endothelial cells (1,...

The sepsis syndrome represents a disease continuum, including severe sepsis and septic shock associated with high mortality. One of the main problems in severe sepsis and septic shock, resulting in organ failure and death, are disturbances in the hemostasis due to sepsis-related coagulopathy. Sepsis-related coagulopathy affects not only traditional coagulation factors, but also the platelets an...

Hypertension is one of the most common medical conditions complicating pregnancy, with significant implications on maternal and perinatal morbidity and mortality. Abnormalities in placentation have been implicated as the primary pathology responsible for the development of hypertension during pregnancy and its effects such as pre-eclampsia and eclampsia. With advancing research, the focus is no...

The first human deaths due to air pollution were recorded in the mid-20th century. There were 6,000 cases of illness recorded in Donora, Pennsylvania, in 1948 and 20,000 in London in 1952; 15 and 4,000 cases of death, respectively, were allegedly ascribed to air pollution. Since then, many countries have adopted standards of air quality in order to protect environmental and human health, althou...

Preservation and storage techniques represent two major issues in routine cardiac surgery and heart transplantation. Historically, these methods were conceived to prevent ischemic injury to myocardium after cardiac arrest during heart operations. Evidence shows that endothelium plays a critical role in the maintenance of normal heart function after cardiac operation, mainly by controlling the c...