نتایج جستجو برای: enkephalin

تعداد نتایج: 2309  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1977
A J Blume J Shorr J P Finberg S Spector

The endogenous central nervous tissue substance called MLC (morphine-like compound) is shown to bind to the opiate receptors of the mouse neuroblastoma X glioma hybrid cell line NG108-15. The interaction of MLC with these opiate receptors is noncooperative, as is the interaction of morphine, naloxone, and Leu-enkephalin with these receptors. A specific antibody to morphine will bind MLC but wil...

Journal: :Headache 1989
J E Hardebo R Ekman M Eriksson

Significantly lower met-enkephalin levels were found in CSF from cluster headache sufferers as compared to age-matched healthy volunteers, whereas it was not possible to demonstrate any clear-cut difference for beta-endorphin. CSF opioid levels may rise following manual or electroacupuncture. It was studied whether traditional Chinese (manual) acupuncture affected CSF levels of met-enkephalin o...

Journal: :British medical journal 1984
T A Howlett S Tomlin L Ngahfoong L H Rees B A Bullen G S Skrinar J W McArthur

Plasma beta endorphin and met-enkephalin concentrations were measured in response to treadmill exercises in 15 normal women before, during, and after an intensive programme of exercise training. Significant release of beta endorphin occurred in all three test runs, and the pattern and amount of release were not altered by training. Before training dramatic release of met-enkephalin was observed...

Journal: :The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1984
M B Hancock

The sequential application of the peroxidase-antiperoxidase (PAP) technique with nickel-intensified DAB and with DAB alone was used to visualize black peptide-immunoreactive endings on amber serotonin-immunoreactive cells in 1-2-micron paraffin sections of the hamster medulla. Met-enkephalin- and substance P-positive terminals were present on serotonin cells in the raphe nuclei, the ventral ret...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1992
H Xu A R Gintzler

Previous work from this laboratory has shown that the electrically evoked release of enkephalin from the guinea pig myenteric plexus is regulated by an opiate receptor-mediated, concentration-dependent mechanism. Low concentrations (nanomolar) of opioids enhance release, whereas higher concentrations (10-100 nM) inhibit release. Each opioid effect is mediated by a different guanine nucleotide-b...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1988
P M Groves M Martone S J Young D M Armstrong

Recent anatomical investigations of the mammalian neostriatum have uncovered discrete neurochemical zones characterized by low levels of AChE and high levels of enkephalin-like immunoreactivity (ELI) compared with the surrounding neostriatal tissue. These regions, termed striosomes, which appear as patches in individual sections, have been associated with specific afferent and efferent pathways...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1985
C Chavkin W J Shoemaker J F McGinty A Bayon F E Bloom

Opioid peptides derived from prodynorphin were localized immunocytochemically to dentate granule cells and mossy fibers of the rat hippocampus with antisera against dynorphin A(1-17) and dynorphin B. Extracts of microdissected hippocampal regions were resolved by reverse phase and molecular exclusion chromatography to identify the molecular forms of the dynorphin A immunoreactivity and to quant...

Journal: :The Journal of biological chemistry 1984
K Yoshikawa C Williams S L Sabol

A cDNA-clone library was constructed from poly-adenylated RNA of Fischer rat striatum and screened for inserts coding for the enkephalin precursor preproenkephalin. The insert of one positive clone, pRPE2, was sequenced and found to contain the coding sequence (810 bases), as well as 316 and 155 bases of the 3' and 5' untranslated regions, respectively, of rat preproenkephalin mRNA. The primary...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
M F Olive B Anton P Micevych C J Evans N T Maidment

Parallel studies have demonstrated that enkephalin release from nerve terminals in the pallidum (globus pallidus and ventral pallidum) can be modulated by locally applied opioid drugs. To investigate further the mechanisms underlying these opioid effects, the present study examined the presynaptic and postsynaptic localization of delta (DOR1) and mu (MOR1) opioid receptors in the dorsal and ven...

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