There exists much variability in susceptibility/resilience to addiction in humans. The environmental enrichment paradigm is a rat model of resilience to addiction-like behavior, and understanding the molecular mechanisms underlying this protective phenotype may lead to novel targets for pharmacotherapeutics to treat cocaine addiction. We investigated the differential regulation of transcript le...

OBJECTIVE Biologically significant amounts of two procoagulant molecules, phosphatidylserine (PS) and tissue factor (TF), are transported by monocyte/macrophage-derived microvesicles (MVs). Because cellular cholesterol accumulation is an important feature of atherosclerotic vascular disease, we now examined effects of cholesterol enrichment on MV release from human monocytes and macrophages. ...

Targeted DNA enrichment coupled with next generation sequencing has been increasingly used for interrogation of select sub-genomic regions at high depth of coverage in a cost effective manner. Specificity measured by on-target efficiency is a key performance metric for target enrichment. Non-specific capture leads to off-target reads, resulting in waste of sequencing throughput on irrelevant re...

Research using twins has found that much of the variability in externalizing phenotypes-including alcohol and drug use, impulsive personality traits, risky sex, and property crime-is explained by genetic factors. Nevertheless, identification of specific genes and variants associated with these traits has proven to be difficult, likely because individual differences in externalizing are explaine...

objective(s):  in our study, graphene oxide-tio2 nanocomposite (go/tio2) was prepared and used for the enrichment of rutin from real samples for the first time.  materials and methods:   the synthesized go/tio2 was characterized by x-ray diffraction, scanning electron microscopy, and ft-ir spectra.  the enrichment process is fast and highly efficient. the factors including contact time, ph, and...

This research (1) analyzed the content of Pb and Cd in water sediment; (2) physical chemical parameters water; (3) determined enrichment factor accumulation index sediments; (4) to identified quality based on Pollution Index (IP) STORET. The analysis was carried out using PCA (Principal Component Analysis) Pearson's correlation, conducted downstream section Musi River, Palembang, a random sampl...