Recent evidence suggests that individuals with certain personality traits are at elevated risk for chronic systemic inflammation. To date, this literature has focused on the related traits of hostility and negative affect (NA). In this study, we examine the covariation of trait measures of hostility and NA with the inflammatory mediators interleukin-6 and C-reactive protein. We also explore whe...

Introduction. Aggressiveness is one of the forms manifestation personality deviations and differentiated by degree intensity from its normal indicators to extreme ones. In activities police officers, aggressiveness acts as a defense mechanism, which often exceeds limits moderately protective reactions reaches level aggression, manifested an inadequate response exposure environmental stimuli. Th...

OBJECTIVE Although considerable evidence implicates hostility in the development of coronary artery disease (CAD), the pathogenic mechanisms remain poorly understood. We have developed a psychophysiological model that holds that altered autonomic nervous system function links psychological traits with CAD outcomes. In laboratory studies, stressors reduce high-frequency (HF) heart period variabi...

Background Bipolar disorder is associated with an increased risk of aggression. However, effective management of hostility and/or agitation symptoms may prevent patients from becoming violent. This analysis investigated the efficacy of the antipsychotic asenapine on hostility and agitation in patients with bipolar I disorder. Methods Data were pooled from three randomized, double-blind, place...

BACKGROUND Hostility is a significant predictor of mortality and cardiovascular events in patients with coronary heart disease (CHD), but the mechanisms that explain this association are not well understood. The purpose of this study was to evaluate potential mechanisms of association between hostility and adverse cardiovascular outcomes. METHODS AND RESULTS We prospectively examined the asso...

OBJECTIVE To test whether reduction in hostility increases autonomic regulation of the heart. METHODS In this randomized controlled trial, participants were 158 healthy adults, aged 20 years to 45 years, who were 1 standard deviation (SD) above national norms on the Cook-Medley Hostility and the Spielberger Trait Anger Indices. Participants also were interviewed, using the Interpersonal Hosti...