INTRODUCTION The response to exogenous epinephrine (Ep) is difficult to predict given the multitude of factors involved such as broad pharmacokinetic and pharmacodynamic between-subject variabilities, which may be more pronounced in children. We investigated the pharmacokinetics and pharmacodynamics of Ep, co-administered with milrinone, in children who underwent open heart surgical repair for ...

Composite coatings are indispensable for protecting the offshore steel materials serviced in splash zone. But mechanical properties of conventional epoxy resin (EP) poor, which would lead to a short-term lifespan. The carbon fiber (CF) with excellent is an ideal filler reinforce EP coating, thus we chemically grafted Ti3C2Tx nanosheets onto CF via dopamine enhance interface adhesion and compati...

Background: Toll-like receptors (TLRs) form the major family of pattern recognition receptors (PRRs) which are involved in the innate immunity. They recognize pathogen-associated molecular patterns (PAMPs) in bacteria, viruses, fungi and parasites. In human, 10 members of this family have been identified so far. Among these TLRs, TLR3, 7, 8 and 9 designed to recognize nucleic acids and expresse...

objective: methotrexate (mtx), as an anti-folate agent, is widely used in the treatment of rheumatic disorders and malignant tumors, however it damages reproductive system in mice. the aim of this research was to study the effects of ethyl pyruvate (ep) on embryo development and oxidative stress changes in the testis of mice treated with mtx. materials and methods: in this experimental study, t...

We describe a sensitive beta-endorphin (beta-EP) radioimmunoassay specific for beta-EP 1-31 applied to human ventricular and lumbar cerebrospinal fluid (CSF). Specificity was documented by reversed-phase HPLC of CSF pools. Simultaneous ventricular and lumbar CSF samples from 13 patients suspected of having normal-pressure hydrocephalus showed median beta-EP values of 2.2 (range 1.7-4.0) and 4.8...

Neuronal migration is an essential feature of the developing nervous system, but the intracellular signaling mechanisms that regulate this process are poorly understood. During the formation of the enteric nervous system (ENS) in the moth Manduca sexta, the migration of an identified set of neurons (the EP cells) is regulated in part by the heterotrimeric guanyl-nucleotide binding protein (G pr...

The experience of work in an entrepreneurial context is saturated with emotional experiences. While the literature on the relation between affect and entrepreneurial performance (EP) is growing, there was no quantitative integration of the results so far. This study addresses this gap and meta-analytically integrates the results from 17 studies (N = 3810) in order to estimate the effect size fo...

OBJECTIVE To assess the incidence of ectopic pregnancy (EP) in hospitals in Conakry, the capital of Guinea, West Africa. Data on EP incidence in developing countries are rare and often out of date, particularly in Africa. METHODS A retrospective study was carried out, examining all cases of EP registered in the medical files of two referral maternity units at the Donka and Ignace Deen univers...