BACKGROUND Vitamin B6, whose main circulating form is pyridoxal 5'-phosphate (PLP), is important in one-carbon metabolism, which is critical for DNA synthesis and DNA methylation, both of which are potentially involved in colorectal carcinogenesis. However, no previous epidemiologic studies have directly evaluated the association of plasma PLP with risk for colorectal neoplasia. METHODS We co...

CONTEXT Limited data exist regarding population-based epidemiologic changes in incidence of infective endocarditis (IE). OBJECTIVE To evaluate temporal trends in the incidence and clinical characteristics of IE. DESIGN, SETTING, AND PATIENTS Population-based survey using the resources of the Rochester Epidemiology Project of Olmsted County, Minnesota. One hundred seven IE episodes occurred ...

Introduction: Injuries are one of the well-known leading causes disability and mortality in all societies. This study aims to determine incidence trend injuries their epidemiologic characteristics Iran. Methods: In a cross-sectional study, injury fatality data from 2008 2016 were obtained registry Ministry Health Medical Education (Iran) analyzed epidemiological pattern injuries. Data using des...

I present some extensions of Bayesian methods to situations in which biases are of concern. First, a basic misclassification problem is illustrated using data from a study of sudden infant death syndrome. Bayesian analyses are then given. These analyses can be conducted directly, or by converting actual-data records to incomplete records and prior distributions to complete-data records, then ap...

The foregoing commentaries demonstrate wide differences between their authors’ choice of terms describing epidemiologic research designs, and in the relative importance they attach to directionality, timing, and sample selection. Nowhere is this more evident than in their discrepant definitions of “prospective” and “retrospective” studies. According to Drs Greenland and Morgenstern, “Prospectiv...

background: data on premature coronary artery disease (cad) are scarce. the tehran heart center's premature coronary atherosclerosis cohort study (thc-pac) is the first study of its kind in the middle east to assess major adverse cardiac events (mace) in young cad patients. methods: the cohort consists of cad patients, males ≤ 45 years old and females ≤ 55 years old. the participants are reside...

Abstract While the effectiveness of lockdowns to reduce Coronavirus Disease-2019 (COVID-19) transmission is well established, uncertainties remain on lifting principles these restrictive interventions. World Health Organization recommends case positive rate 5% or lower as a threshold for safe reopening. However, inadequate testing capacity limits applicability this recommendation, especially in...

BACKGROUND Sensors detect the rate and direction of glucose trend. They need to be accurate and reproducible as could be evidenced by strong agreement between multiple sensors. We evaluated this relationship through simultaneously worn glucose sensors using several methods of slope analysis. METHODS Ten type 1 diabetic, insulin pump-treated subjects were studied while simultaneously wearing t...

BACKGROUND/AIM Oesophageal cancer is the sixth most common cause of death from all malignant tumors in the world (fifth in men, eighth in women). This cancer was estimated to account for about 529 000 new cases and about 442 000 deaths in the year 2007. In the year 2002 the highest standardized mortality rates (per 100 000 habitants) of oesophageal carcinoma were noticed in the East Asia (men/w...