Zinc homeostasis in the brain is associated with the etiology and manifestation of epileptic seizures. Adult Noda epileptic rats (NER, >12-week-old) exhibit spontaneously generalized tonic-clonic convulsion about once a day. To pursue the involvement of synaptic Zn(2+) signal in susceptibility to spontaneous seizures, in the present study, the effect of zinc chelators on epileptogenesis was exa...

BACKGROUND Previous studies have suggested that maternal cigarette smoking and alcohol drinking during pregnancy may increase risk for febrile convulsion during childhood. We evaluated the relationship of maternal smoking, alcohol drinking, and their interaction on febrile convulsion. METHOD Pregnant women (n=10,108) enrolled in the Child Health and Development Studies in California between 1...

OBJECTIVES To identify the incidence of perioperative convulsion within 24 hours, outcome, predisposing risk factors, contributing factors related to anesthesia and corrective strategies. MATERIAL AND METHOD The prospective cohort study enrolled all anesthetics from twenty eligible hospitals in Thailand between March 1, 2003, and February 28, 2004. Postoperative convulsion incidents were extr...

BACKGROUND AND OBJECTIVE Febrile convulsion is a common disorder in children. Viral infections such as human herpes virus 6 (HHV-6) which results in roseola infantum may contribute to developing seizure. The objective of this study was to determine the prevalence of HHV-6 by detecting DNA in cerebrospinal fluid (CSF) of children with febrile convulsion and without any rash of roseola infantum. ...

The present investigation was aimed to study an antiepileptic activity of methanolic extract of Tragia involucrata Linn in mice. In vivo screening models like maximal electroshock-induced convulsion (MES), pentylenetetrazole (PTZ) and picrotoxin (PTX) induced models are used to evaluate the antiepileptic effects of the extracts. The biochemical estimation was done by measuring the lipid peroxid...

introduction: febrile convulsions occur in young children when there is a rapid increase in their body temperature. it affects up to 1 in 20 children between the ages of one and four but can affect children between six months and about five years old.  previous studies have showed relationship between low serum sodium and calcium level and recurrence of febrile convulsions. this study designed ...

uch of the medicine we practice is enshrined in dogma. The management of children following febrile seizures is no exception. Every 5–10 years, the value and need for various investigations or treatment has been revisited in the medical press. However , despite the commonness of this clinical problem, consensus over management remains elusive. In particular, the need for lumbar puncture followi...