In this review, we will discuss in four scenarios our challenges to offer possible solutions for the puzzle associated with epilepsies and neuropsychiatric comorbidities. We need recognize that (1) since quite old times, human wisdom was linked plural (distinct global places/cultures) perception of Universe are in, deep respect earth nature. Plural ancestral knowledge added scientific methods; ...

We analyzed sexual function in 29 women suffering from focal epilepsy using the Female Sexual Function Index, Beck Depression Inventory, Beck Anxiety Inventory and a battery of laboratory tests were performed to find possible correlations and differences. A total FSFI score lower than the predefined cut-off score was found in 20.7% women and the presence of at least one subtype of sexual dysfun...

This paper aims to honor the memory of the alienist Louis Delasiauve (1804-1893). His classification of the different types of epilepsy based on clinical symptoms is still relevant today and made him a precursor of contemporary epileptology. In 1851, Delasiauve clinically and etiologically isolated 'acute mental confusion' (acute confusional state) from all other forms of dementia. Never deviat...

PURPOSE Patient-reported seizure counts represent a key outcome measure for individual treatments and clinical studies in epileptology. Video-EEG based research, however, demonstrated lack of validity due to underreporting. Here we examined the practice of keeping seizure diaries and the patients' attitudes toward seizure counting. METHODS Anticipating a low return rate, a comprehensive surve...

Objectives. Minimally invasive procedures for treating temporal lobe epilepsy have been investigated recently, namely stereotactic and gamma knife amygdalohippocampectomy (AHE). However, the results are not fully satisfactory. Our aim was to evaluate efficacy and side-effects of stereotactic AHE mimicking the neurosurgical procedure in terms of extent of the lesion. Methods. 16 consecutive pati...

The electroencephalography (EEG) is a well-established non-invasive method in neuroscientific research and clinical diagnostics. It provides high temporal but low spatial resolution of brain activity. To gain insight about the dynamics EEG, one has to solve inverse problem, i.e., finding neural sources that give rise recorded EEG problem ill-posed, which means more than configuration can evoke ...

Abstract Central nervous system tumors and their treatments can cause neurologic, cognitive, psychiatric symptoms that restrict a patient’s ability to work. In the United States, diagnosis of high-grade glioma (grade 3 or 4) medically qualifies patient for disability benefits through Social Security. Low-grade gliomas be similarly debilitating, with at least 50% patients presenting one more cog...