Epithelial-to-mesenchymal transition (EM transition) is a process wherein epithelial cells lose their intrinsic characteristics and cell–cell junctions differentiate into mesenchymal phenotype. EM an important feature of cancer invasion metastasis. In this study, we aimed to investigate the inhibitory effect gintonin (GT), ingredient ginseng, on using A549 cells. The proliferation was enhanced ...

Epithelial–mesenchymal transition (EMT) is a process during which cells lose their epithelial characteristics, for instance apical–basal cell polarity and cell–cell contact, gain mesenchymal properties, such as increased motility. In colorectal cancer, EMT has an important role in tumour progression, metastasis, drug resistance. There been accumulating evidence from preclinical early clinical s...

Versican is a large extracellular chondroitin sulfate proteoglycan that belongs to the family of lecticans. Alternative splicing of versican generates at least four isoforms named V0, V1, V2, and V3. We show here that ectopic expression of versican V1 isoform induced mesenchymal-epithelial transition (MET) in NIH3T3 fibroblasts, and inhibition of endogenous versican expression abolished the MET...

29 The outcome of liver injury is determined by the success of repair. Liver repair 30 involves replacement of damaged liver tissue with healthy liver epithelial cells 31 (including both hepatocytes and cholangiocytes), and reconstruction of normal 32 liver structure and function. Current dogma posits that replication of surviving 33 mature hepatocytes and cholangiocytes drives the regeneration...

The outcome of liver injury is determined by the success of repair. Liver repair involves replacement of damaged liver tissue with healthy liver epithelial cells (including both hepatocytes and cholangiocytes) and reconstruction of normal liver structure and function. Current dogma posits that replication of surviving mature hepatocytes and cholangiocytes drives the regeneration of liver epithe...