Mild traumatic brain injury (mTBI) produces symptoms similar to those typifying posttraumatic stress disorder (PTSD) in humans. We sought to determine whether a rodent model of stress concurrent with mTBI produces characteristics of PTSD such as impaired contextual fear extinction, while also examining concurrent alterations to limbic monoamine activity in brain regions relevant to fear and anx...

The objective of the present study was to evaluate the interaction of two kinds of external stimuli (long-term tactile stimulation and underwater trauma) on the exploratory behavior of malnourished rats in an elevated plus maze (EPM). The results showed that tactile stimulation partially recovered body weight deficits produced by malnutrition and decreased EPM exploration. Malnutrition increase...

Chen et al. in 2004 proposed a new hierarchy structure, called the enhanced pyramid network (EPM, for short), by replacing each mesh in a pyramid network (PM, for short) with a torus. Recently, some topological properties and communication on the EPMs have been investigated or derived. Their results have revealed that an EPM is an attractive alternative to a PM. This study investigates the node...

After prolonged treatment in horses for equine protozoal myeloencephalitis (EPM), cerebrospinal fluid antibodies to Sarcocystic neurona may persist. The albumin quotient did not change and the IgG index decreased in horses with EPM after repeated spinal taps 2–3 months apart. A decrease in IgG index, a measure of intrathecal antibody production, may indicate a favorable response to treatment fo...

Several variables, including age, are known to influence anxiety. Previous exposure to the elevated-plus maze (EPM) is known to modify emotional behaviour as retesting in the EPM at a standard age of 3 months increases open-arm avoidance and attenuates the effects of anxiolytic drugs. This study analysed whether similar results are obtained when older animals are subjected to these experimental...

Background: Toxoplasma gondii is a neurotropic parasite with lifelong persistence in the host brain. Many researchers suggested toxoplasmosis as risk factor for development of Alzheimer's disease (AD); however, link between them has not been fully elucidated. Objectives: The present study was designed to investigate effects chronic infection Types I (RH), II (PRU), and III (VEG) strains alone c...

Cholesterol in milk is derived from the circulating blood through a complex transport process involving the mammary alveolar epithelium. Details of the mechanisms involved in this transfer are unclear. Apolipoprotein-AI (apoA-I) is an acceptor of cellular cholesterol effluxed by the ATP-binding cassette (ABC) transporter A1 (ABCA1). We aimed to 1) determine the binding characteristics of (125)I...

Equine protozoal myeloencephalitis (EPM) is a serious neurological disease of horses in the Americas. The protozoan most commonly associated with EPM is Sarcocystis neurona. The complete life cycle of S. neurona is unknown, including its natural intermediate host that harbors its sarcocyst. Opossums (Didelphis virginiana, Didelphis albiventris) are its definitive hosts. Horses are considered it...

Equine protozoal myeloencephalitis (EPM) has been widely described in the veterinary literature. Even in appropriately treated horses it can be a progressive, debilitating neurological disease. Either of the known causative agents, Sarcocystis neurona (common) and Neospora hughesi (rare), can produce signs of focal or multifocal central nervous system disease. Although spinal ataxia and weaknes...