نتایج جستجو برای: epothilone a
تعداد نتایج: 13431870 فیلتر نتایج به سال:
Central nervous system injury, specifically traumatic brain and spinal cord can have significant long lasting effects. There are no comprehensive treatments to combat the injury sequalae of events that occurring following a central trauma. Herein we discuss potential for epothilone family microtubule stabilizing agents improve outcomes experimentally induced These drugs, which able cross blood-...
A three-dimensional quantitative structure-activity relationship (3D QSAR) study has been carried out on epothilones based on comparative molecular field analyses (CoMFA) using a large data set of epothilone analogs, which are potent inhibitors of tubulin depolymerization. Microtubules, which are polymers of the a/beta-tubulin heterodimer, need to dissociate in order to form the mitotic spindle...
PURPOSE Vinca alkaloids, agents that cause depolymerization of microtubules, are highly active in treatment of many pediatric cancers. In contrast, taxanes, agents that stabilize microtubules, are far less effective against the same cancer types. The purpose of the current study was to evaluate the antitumor activity of ixabepilone, an epothilone B derivative representing a new class of microtu...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید