Artificial inflation of corpora cavernosa from the nine-banded armadillo (Dasypus novemcinctus) showed that the expansion of the tunica albuginea during erection increases both components of flexural stiffness: the second moment of area and Young's modulus of elasticity. Folded tissue and crimped collagen fibers in the tunica albuginea permit its expansion during erection. As the tunica albugin...

Impotence is syndrome involving the interaction of psychogenic, hormonal, neurological, arterial, venous & sinusoidal factors. Management of impotence has evolved from a time-born pattern of sympathetic discussion and empiric use of medication to a scientifically planned diagnostic protocol and specific treatment regime. The present study was undertaken to assess the effects of pharmacologicall...

The erectile status of penile tissue is governed largely by the tone of cavernosal smooth muscle cells, which is determined by the balance of vascular relaxants and constrictors. Vascular relaxants play a key role in regulating the tone of cavernosal smooth muscle and thus the initiation and maintenance of penile erection. Early studies drew attention to the potential role of adenosine signalin...

Erectile dysfunction is a serious and common complication of diabetes mellitus. The proposed mechanisms for erectile dysfunction in diabetes include central and autonomic neuropathy, endothelial dysfunction, and smooth muscle dysfunction. The paraventricular nucleus (PVN) of the hypothalamus is known to be involved in centrally mediated penile erection. This study was designed to examine the ro...

OBJECTIVE To determine whether a defect in vasoactive intestinal peptide (VIP)-mediated vasodilatation underlies diabetic impotence. MATERIALS AND METHODS Rats treated with streptozotocin for 8 weeks developed diabetes, as shown by hyperglycaemia and glycosuria, and had significant impairment of sexual function, as determined by tests of sexual behavior. The VIP content of the penis and major...

PURPOSE We performed sham controlled evaluation of penile low intensity shock wave treatment effect in patients unable to achieve sexual intercourse using PDE5i (phosphodiesterase type 5 inhibitor). MATERIALS AND METHODS This prospective, randomized, double-blind, sham controlled study was done in patients with vasculogenic erectile dysfunction who stopped using PDE5i due to no efficacy. All ...

Previous research has highlighted the efficacy of the application of lean production principles in the precast concrete industry. The work also highlighted the dependence of engineered-to-order prefabrication in construction on both engineering and on process control information for production in construction. In current practice in most precast/prestressed plants in the US, producers typically...