Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection [1]. The syndrome is characterised by autonomic dysfunction and increased plasma levels of noradrenaline and adrenaline [2]. These catecholamines originate mainly from the activated sympathetic nervous system, but also originate from the adrenal gland, gut, and immune cells [3]. While nec...

BACKGROUND The advent of laparoscopic surgery has benefited the patient and surgeon; however creation of pneumoperitoneum for same has bearings during the perioperative period. These effects of pneumoperitoneum are associated with significant haemodynamic changes, increasing the morbidity of the patient. AIM The present study compared the efficacy of dexmedetomidine and esmolol on hemodynamic...

BACKGROUND Although various reports have shown that β-antagonists provide neuroprotective effects after cerebral ischaemia, their effect on spatial memory after transient focal ischaemia is not known. We investigated the treatment of β1-antagonists on neurological outcome spatial memory for 1 month after focal cerebral ischaemia in rats. METHODS Male rats randomly received an i.v. infusion of...

Laryngoscopy and intubation increases blood pressure and heart rate. The study aims to investigate the effect and safety of gabapentin, clonidine or esmolol on the haemodynamic response to laryngoscopy and intubation. Fiftysix ASA I and II patients undergoing elective surgery were randomly allocated to one of the four groups. First study drug was administered orally as gabapentin 1200mg or clon...

CONTEXT Electroconvulsive therapy (ECT) is associated with tachycardia and hypertension. AIMS The aim of this study was to compare two doses of dexmedetomidine, esmolol, and lignocaine with respect to hemodynamics, seizure duration, emergence agitation (EA), and recovery profile. METHODOLOGY Thirty patients undergoing ECT were assigned to each of the following pretreatment regimes over the ...

RATIONALE Induction of heme oxygenase-1 (HO-1) protects the liver against reperfusion injury after hemorrhagic shock. Previous data suggest that the beta(1)-adrenoceptor agonist dobutamine induces HO-1 in hepatocytes. OBJECTIVES To investigate the functional significance of dobutamine pretreatment for liver function after hemorrhagic shock in vivo. METHODS Anesthetized rats received either ...

There has been a great deal of interest in the therapeutic role of beta-adrenergic blockade in patients suffering from vasovagal syncope. The efficacy of beta-blockers in these patients may be due to blunting of elevated catecholamine levels that precede vasovagal syncope (1). Notwithstanding the widespread use of beta-blockers in the past, some studies on chronic beta-blocker use have been les...

OBJECTIVE To assess the effect of esmolol added to propofol-remifentanil combination for hypotensive anesthesia on hemodynamic conditions, consumption of anesthetic drugs, and recovery, during elective septorhinoplasty. METHODS This prospective, randomized study was carried out at Gazi University, Faculty of Medicine, Ankara, Turkey in 2005. Following Institutional Ethical Committee approval,...

Context Laryngoscopy and endotracheal intubation lead to strong sympathetic response which may precipitate arrhythmias, myocardial ischemia and cerebrovascular accidents in patients with preexisting cardiovascular disease. Aims This study was aimed to compare the effect of dexmedetomidine and esmolol on hemodynamic response to laryngoscopy and endotracheal intubation in patients undergoing el...