Gastroesophageal reflux disease (GERD) is a chronic disorder of the upper gastrointestinal tract with global distribution. The incidence is on the increase in different parts of the world. In the last 30 to 40 years, research findings have given rise to a more robust understanding of its pathophysiology, clinical presentation, and management. The current definition of GERD (The Montreal definit...

Noncardiac chest pain (NCCP) is one of the most common esophageal symptoms and lacks a clearly defined mechanism. The most common cause of NCCP is gastroesophageal reflux disease (GERD). One of the accepted mechanisms of NCCP in a patient without GERD has been altered visceral sensitivity. Mast cells may play a role in visceral hypersensitivity in irritable bowel syndrome. In this case, a patie...

HYPOTHESIS Risk factors for the presence and extent of Barrett esophagus (BE) can be identified in patients with gastroesophageal reflux disease (GERD). DESIGN Case-comparison study. SETTING University tertiary referral center. PATIENTS Five hundred two consecutive patients with GERD documented by 24-hour esophageal pH monitoring and with complete demographic, endoscopic, and physiologica...

Barrett's esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC), a disease with increasing burden in the Western world, especially in white men. Risk factors for BE include obesity, tobacco smoking, and gastroesophageal reflux disease (GERD). EAC is the most common form of esophageal cancer in the United States. Risk factors include GERD, tobacco smoking, and obesity, whereas nonst...

PURPOSE OF REVIEW Patients with gastroesophageal reflux disease (GERD) who are not responding to proton pump inhibitors (PPIs) given once daily are very common. These therapy-resistant patients have become the new face of GERD in clinical practice in the last decade and presently pose a significant therapeutic challenge to the practicing physician. We reviewed newly accumulated information abou...

Introduction: Atrial arrhythmia is a common complication in patients with gastro esophageal reflux disease (GERD). The treatment of palpitation is relatively problematic in these patients, especially if there is not enough evidence of cardiovascular or systemic diseases. The esophagus is in close proximity to the left atrium posterior wall. Hypothetically, locally released cytokines from esopha...

BACKGROUND/AIMS The impact of aging on esophageal motility is not completely understood. This study aims at assessing 1) whether degeneration of esophageal body motility occurs with age and 2) whether this development is influenced by gastroesophageal reflux disease (GERD). METHODS 326 consecutive patients with symptoms of GERD underwent a diagnostic work-up including a water-perfused esophag...

____________________________________________________________________________________________________________ Introduction Gastro-esophageal reflux disease (GERD) is said to affect 4 to 7 percent of the US population and is on the rise. Over the past 3 decades, the prevalence of GERD has increased two-fold, and some sources estimate prevalence between 10 to 20 percent.1, 2 It is characterized by...

Until relatively recently, gastroesophageal reflux disease (GERD) was thought to be a relatively trivial problem, and pharmaceutical companies initially had remarkably little interest in clinical trials for GERD. Over the last ten years, GERD therapy has become the subject of intense interest, since reflux disease is now recognized as a major market for antisecretory and prokinetic drugs. Even ...

J Dent Health Oral Disord Ther 2016, 5(5): 00170 Abbreviations: CREST: Calcinosis Raynaud Phenomenon Esophageal Dismotility Sclerodactyly Teleangiectasia; GERD: Gastro Esophageal Reflux Disease; CD: Celiac Disease; RAS: Recurrent Aphthous Stomatitis; MiRAS: Mikulicz’s Aphthae; MaRAS: Sutton’s Aphthae; HeRAS: Herpetiform Aphthae; PFAPA: Periodic Fever Aphthous Stomatitis Pharyngitis and Adenitis...