Upregulation of aromatase (estrogen synthase) in glia around the site of neural injury may limit neural degeneration. Systemic administration of estrogen limits neural damage, but the specific role of local estrogen provision in this effect is unclear. In male zebra finches, we tested the effect of local aromatase inhibition and estrogen replacement on type of cellular degeneration and the dist...

Osteoporosis is a major public health problem. Exogenous estrogen or Hormone Replacement Therapy (HRT) the potential therapy for osteoporosis. Still, patient rarely chooses this treatment because of risk breast and endometrial cancer. Phytoestrogens estrogen-like compounds, particularly isoflavones, are potentially safe alternative to HRT. Jicama (Pachyrhizus erosus) plant that contains many ph...

Understanding effects of estrogen on the medial prefrontal cortex (PFC) may help to elucidate the increased prevalence of depression and post-traumatic stress disorder in women of ovarian cycling age. Estrogen replacement in ovariectomized (OVX) young rats amplifies the detrimental effects of stress on working memory (a PFC-mediated task), but the mechanisms by which this occurs have yet to be ...

The human embryo develops into a woman as a result of estrogen. It helps maintain our breasts, genitalia, vagina, cervix, and parts of our urinary tract. These tissues are estrogen sensitive. Estrogen, though beneficial in many ways to women, has also been linked to cancer of the breast, uterine lining, and cervix. Excessive amounts of estrogen and prolonged exposure to it, can increase our ris...

Female Sprague–Dawley rats were ovariectomized at 13 months of age. Four groups received different regimens of estrogen or estrogen plus progesterone replacement beginning either immediately, 3 months, or 10 months after ovariectomy and were compared with non-hormone-treated controls. Eight to twelve months after ovariectomy, animals were trained on a delayed matching-to-position (DMP) spatial ...

Walsh • Focus on cardiovascular health C disease is the leading cause of death in the United States today. Fully 52% of women will die of cardiovascular disease, far exceeding the percentage who will die of all cancers combined, and far in excess of the 4% who will die of breast cancer.1 It has been known since the initial findings of the Framingham Study, however, that women have a 20-year adv...

BACKGROUND Improvement in endothelial function may be an important mechanism by which estrogen replacement therapy protects postmenopausal women against coronary artery disease. However, combined hormone replacement therapy is more frequently used owing to the risk of uterine cancer with estrogen-only therapy. Concurrent progesterone treatment may attenuate the beneficial effects of estrogens n...

BACKGROUND We determined whether the vascular effects of estradiol depend on the route of administration by comparing the effects of oral estradiol and transdermal placebo, transdermal estradiol and oral placebo, and transdermal placebo and oral placebo on in vivo endothelial function in 27 postmenopausal women. METHODS AND RESULTS Endothelial function was assessed from blood flow responses t...

Alzheimer's disease (AD) is accompanied by chronic neuroinflammation and occurs with greater incidence in postmenopausal women. The increased incidence may be delayed by estrogen replacement therapy (ERT). The authors investigated the interaction of chronic ERT and lipopolysaccharide (LPS)-induced neuroinflammation in the female rat. Ovariectomy did not impair water maze performance; however, a...

A 47 year old woman receiving oestrogen replacement therapy for primary amenorrhoea presented with recurrent chylothorax. The clinical and radiological features of her illness were characteristic of pulmonary lymphangio-leiomyomatosis, a rare hormone-dependent disease. The condition was treated with pleurodesis and withdrawal of oestrogen therapy.