We present a patient who, over the course of 35 years, presented with repeated episodes of ileus and melena and was misdiagnosed several times, leading to several surgeries. Macroscopic and microscopic features of his resected intestine were compatible with cryptogenic multifocal ulcerous stenosis enteritis (CMUSE), but additional angioectatic lesions were also noted. The patient responded dram...

Optimization of an analytical method for determination of steroid estrogens, through minimizing sample size, resulted in recoveries >84%, with relative standard deviations <3% and demonstrated the significance of sample size on method performance. Limits of detection were 2.1-5.3 ng/g. Primary sludges had estrogen concentrations of up to one order of magnitude less than those found in biologica...

Since the recent publication of our study on the comparative effectiveness of combined oral contraceptives (COCs) in relation to progestogen type, length of pill-free interval and body mass index (BMI) during typical clinical use,1 we have received requests for further information. Specifi cally, we were asked if adolescents, who are known to have higher missed pill rates and thus higher uninte...

The 1 H and 13 C NMR spectra of 17-α-ethinylestradiol (EE2), a well-known contraceptive, including diastereotopic methylene groups, were fully assigned with the help of residual dipolar couplings (RDC) measured in the recently developed grafted graphene oxide orienting medium. RDC analysis, which included all 1 DCH couplings and the long-range 2 DCH1 H-C≡13 C coupling, also pointed to the prese...

a review of the evidence and an extensive consultation process, the WHO recommendations were endorsed by the FFPRHC.1 Different rules for pills containing 20 μg or 30 μg ethinylestradiol are appropriate to minimise intervention for the majority of women without risking contraceptive efficacy. The risk of pregnancy is greatest when pills are missed either side of the pill-free interval (PFI) and...

BACKGROUND Primary aldosteronism is recognized as the most frequent cause of secondary hypertension. Screening for primary aldosteronism by determination of the aldosterone-to-renin ratio (ARR) is much more frequently performed in current practice. However, most antihypertensive medications interfere with ARR determination, and although verapamil and alpha-adrenergic blockers are considered suf...