[Editorial Note: The Pioneer Health Centre at Peckham (often called the Peckham Health Centre) has recently attracted a good deal of historical attention, including an article in this journal by Jane Lewis and Barbara Brookes (Med. Hist., 1983,27: 151-161). The author of the present article, Dr Kenneth Barlow, has long been associated with the Pioneer Health Centre Ltd, presently serving as its...

Knowledge of hydrogen bonds is important in a wide range of scientific fields. However, information on the electronic state of hydrogen bonded molecules in liquids and solutions is still limited. We applied X-ray emission and absorption spectroscopy to observe the electronic state around oxygen of water and investigate the solvent dependence of occupied and unoccupied valence electronic states ...

For the last three decades the interest in biomonitoring and ecological studies has been rapidly growing. Therefore, it was necessary develop of new methods of analysis for biochemical parameters which allow to quantify biological response of investigated organisms for environmental factors. The main goal of this paper demonstrates optimal conditions for enzyme kinetics analysis conducted in th...

Hollow CdS nanoboxes, having paper-thin walls of well-defined facets, were synthesized at 170 degrees C via a simple reaction using Na(2)SeO(3) for interior quasitemplates and ethylenediamine for exterior molecular templates.

Homeostasis in eukaryotic tissues is tightly regulated by an intricate balance of the prosurvival and antisurvival signals. The tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10), a dual-specificity phosphatase, plays a functional role in cell cycle arrest and apoptosis. NF-κB and its downstream regulators (such as VEGF) play a central role in prevention of apoptosi...

Acute generalized exanthematous pustulosis (AGEP) is characterized by acute onset of fever with a generalized erythematous pustular eruption. It seems that more than 90% of cases with AGEP are drug-induced [1]. The most frequently involved drugs are aminopenicillins, macrolides, antimycotic drugs, calcium channel blockers, carbamazepine, and paracetamol. We report a severe case of topical drug–...

We describe the synthesis of N -functionalised phosphinecarboxamides obtained by reaction 2-phosphaethynolate anion (PCO ? ) with diamines, specifically hydrazine, methylenediamine and ethylenediamine.

A zwitterionic bis(guanidinium) ionophore bearing an anionic closo-borane cluster (1) and a dihydrochloride analogue (2) are investigated in polymeric membrane ion-selective electrodes (ISEs). Both compounds have been previously shown to complex and selectively extract oxoanions. By systematic variation of the kind and concentration of the ion-exchanger sites in the membrane, the optimal perfor...

The concentrations of cefotiam dihydrochloride (CTM) in maternal and fetal blood and in amniotic fluid were determined by bioassay in 38 women at parturition. With an intravenous infusion of 1 g of CTM, the decline in concentration of CTM in maternal blood was biphasic; CTM was not detectable at 6 h after administration. Peak levels of CTM in umbilical cord blood (13.0 to 23.9 micrograms/ml) w...