BACKGROUND Microencapsulation is a useful method to prolong a drug release from dosage forms and to reduce its adverse effect (1) among various available methods. The microencapsulation of hydrophilic active ingredients requires the use of a polar dispersing phase such as a mineral oil. Acetone/paraffin systems are conventionally used. OBJECTIVES The current study aimed to investigate two dif...

Author’s E-mail: [email protected] Tel:+964-7702660991 In an attempt to combine the favourite properties of hard gelatine capsules with the protective and controlled release properties of enteric coating to get an appropriately and acceptably formulated enteric coated hard gelatine capsules with pH dependent drug release characteristic. Two hard gelatine capsule sizes were selected i.e. siz...

Diclofenac sodium as ophthalmic dosage form is used in patients treatment of eye pain, swelling and redness recovering from cataract surgery but it faces the bioavailability limitation of eye drops due to effective protective mechanisms and corneal barrier functions in the eyes. Therefore, this investigation was aimed to develop ocular film formulations to achieve controlled drug release. Drug ...

E-mail: [email protected] The objectives of the present investigation were: (1) to elucidate the effect of formulation variables e.g., amount of Eudragit RS 100, concentration of Tween 80 and agitation speed on in-vitro release profiles of indomethacin from multiparticulates system, formulated with the combination of ethyl cellulose and Eudragit RS 100 by using a novel quasi emulsion solve...

In this paper, different formulation types of microparticulate systems such as beads, microbeads, microspheres and microsponges using to special attention chitosan, alginate and eudragit RS 100 are reviewed. Chitosan and alginates are natural, anionic or cationic, biocompatible, biodegredable and non-toxic polymers. They have excellent potential for pharmaceutical and biopharmaceutical applicat...

The aim of this study was to evaluate the suitability of Raman spectroscopy as a Process Analytical Technology (PAT) tool for the in-line determination of the active pharmaceutical ingredient (API) concentration and the polymer-drug solid state during a pharmaceutical hot-melt extrusion process. For in-line API quantification, different metoprolol tartrate (MPT)--Eudragit® RL PO mixtures, conta...

background microencapsulation is a useful method to prolong a drug release from dosage forms and to reduce its adverse effect (1) among various available methods. the microencapsulation of hydrophilic active ingredients requires the use of a polar dispersing phase such as a mineral oil. acetone/paraffin systems are conventionally used. objectives the current study aimed to investigate two diffe...

diclofenac sodium as ophthalmic dosage form is used in patients treatment of eye pain, swelling and redness recovering from cataract surgery but it faces the bioavailability limitation of eye drops due to effective protective mechanisms and corneal barrier functions in the eyes. therefore, this investigation was aimed to develop ocular film formulations to achieve controlled drug release. drug ...