Hemodynamic responses to cocaine vary greatly between animals, and the variability is related to the incidence of cocaine-induced cardiomyopathies and hypertension. The variability in cardiac output and systemic vascular resistance responses to cocaine in individuals is correlated with the responses to acute startle (air jet). This experiment was designed to determine whether responses to cocai...

Objective(s):To determine the effect of acetylcholine (ACh), pilocarpine, and atropine on pain evoked responses of pain excited neurons (PEN) and pain inhibited neurons (PIN) in hippocampal CA3 region of morphine addicted rats. Materials and Methods:Female Wistar rats, weighing between 230-260 g were used in this study. Morphine addicted rats were generated by subcutaneous injection of increasi...

BACKGROUND Variability in patients' postoperative pain experience and response to treatment challenges effective pain management. Variability in pain reflects individual differences in inhibitory pain modulation and psychological sensitivity, which in turn may be clinically relevant for the disposition to acquire pain. The aim of this study was to investigate the effects of conditioned pain mod...

There is increasing interest in the role gamma oscillations ( approximately 40 Hz) play in visual information processing. Despite this interest, and in contrast to the classically studied visual evoked potential, surprisingly little is known about the intra-individual repeatability of induced gamma oscillations. Similarly, little is known about inter-individual variability in terms of gamma osc...

Background: Brainstem auditory evoked responses (BAERs) are electrophysiological investigations have widespread clinical utility in neurology, audiology, neonatology and anesthesiology. BAER responses exhibit a normal variability due to various non-pathologic factors and age is one of the variables suggested to have considerable influence on normal BAE responses. Aging changes in the auditory s...

introduction: the bed nucleus of the stria terminalis (bst) is a limbic structure which is involved in cardiovascular regulation and baroreflex modulation. the presence of cholinergic synaptic terminalis with high level of muscarinic receptors in the bst has been demonstrated. this study was performed to find the role of the cholinergic muscarinic receptor in cardiovascular response and baroref...

Cortical inhibitory interneurons (INs) are subdivided into a variety of morphologically and functionally specialized cell types. How the respective specific properties translate into mechanisms that regulate sensory-evoked responses of pyramidal neurons (PNs) remains unknown. Here, we investigated how INs located in cortical layer 1 (L1) of rat barrel cortex affect whisker-evoked responses of L...