Objective Improvement in ex vivo lung perfusion protocols could increase the number of donors available for transplantation and protect lungs from primary graft dysfunction. We hypothesize that perfusate adsorption during reconditions allograft to ischemia–reperfusion injury after transplantation. Methods Donor pig were preserved 24 hours at 4°C, followed by 6 according Toronto protocol. The wa...

Twenty-five years have passed since the first lung transplant was performed at the Instituto do Coração (INCOR) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. On October 16, 1990, a 26-year-old woman with severe pulmonary fibrosis and secondary pulmonary hypertension underwent a single left lung transplant but only survived for 12 days, dying due to sepsis and d...

Lung transplantation has come to be viewed as the best treatment option for various end-stage lung diseases. The low number of viable donors continues to be a major obstacle to increasing the number of lung transplants, resulting in high mortality among patients on the waiting list. Unlike transplantation of other solid organs, lung transplantation is primarily limited not by the absolute numbe...

Lung transplantation has come to be viewed as the best treatment option for various end-stage lung diseases. The low number of viable donors continues to be a major obstacle to increasing the number of lung transplants, resulting in high mortality among patients on the waiting list. Unlike transplantation of other solid organs, lung transplantation is primarily limited not by the absolute numbe...