Frovatriptan, a 5-HT1B and 5-HT1D receptor agonist, is used for the treatment of acute migraine attack. This molecule is classified into second line therapy because of its slow onset of action (peak response obtained after 4 hours of administration) and low bioavailability (25%). Moreover, its therapy is the most costly among all triptans. Attempt has been made in present work to suggest a way ...

In earlier studies insects were proposed as suitable models for vertebrate blood-brain barrier (BBB) permeability prediction and useful in early drug discovery. Here we provide transcriptome and functional data demonstrating the presence of a P-glycoprotein (Pgp) efflux transporter in the brain barrier of the desert locust (Schistocerca gregaria). In an in vivo study on the locust, we found an ...

Nanoparticles that readily penetrate mucosal layers are desirable for a variety of biomedical applications. Nevertheless, most nanoparticles tend to be immobilized in mucus via steric and/or adhesive interactions. Contrary to the established opinion that poly(vinyl alcohol) (PVA) is mucoadhesive, we discovered that coating otherwise mucoadhesive nanoparticles with certain partially hydrolyzed P...

Diclofenac sodium loaded solid lipid nanoparticles (SLNs) were formulated using guggul lipid as major lipid component and analyzed for physical parameters, permeation profile, and anti-inflammatory activity. The SLNs were prepared using melt-emulsion sonication/low temperature-solidification method and characterized for physical parameters, in vitro drug release, and accelerated stability studi...

Abstract Purpose Amorphous solid dispersions (ASD) for nasal delivery offer the opportunity to increase drug release performance, while using polymers with mucoadhesive properties. The aim of present study was apply this solubility enhancement technique a poorly soluble delivery, comparing two particle engineering strategies, namely spray dried microparticles and chimeral agglomerates, correspo...

PURPOSE The purpose of this study was to formulate ketoprofen (KET)-loaded Eudragit L and Eudragit S nanofibers (NFs) by the electrospinning technique for buccal administration to treat oral mucositis as a safe alternative to orally administered KET, which causes gastrointestinal tract (GIT) side effects. MATERIALS AND METHODS NFs were prepared by electrospinning using Eudragit L and Eudragit...

Objectives: The objective of existent effort was topical proniosomal gel formulation and evaluation from the proniosomes Ciclopirox to improve poor skin penetration residence antifungal drugs. Methods: co-acervation phase separation method used prepare by using combination different grades non-ionic surfactant, cholestrol lecithin. Characterized for pH, encapsulation efficiency, Particle size, ...

In skin penetration studies, HPLC-MS/MS analysis on extracts of heat-separated epidermis and dermis provides an estimate the amount drug penetrated. this study, MALDI-MSI enabled qualitative distribution endogenous molecules molecule, tofacitinib quantitative in epidermis. The delivery to was investigated a Franz diffusion cell using three different formulations (two oil-in-water creams, C1 C2 ...

Objective: The present research was aimed to develop ketoconazole (KT) loaded microemulsion-based gel formulation for effective topical delivery through enhanced drug solubility, improved skin permeation and reduced side effects overcoming drawbacks of conventional dosage forms. Methods: For the selection oil, surfactant co-surfactant mixture (Smix) ratio, phase titration method used pseudo-ter...