About a third of the human population is estimated to be infected with Mycobacterium tuberculosis. The bacterium displays an excellent adaptability to survive within the host macrophages. As the reactive environment of macrophages is capable of inducing DNA damage, the ability of the pathogen to safeguard its DNA against the damage is of paramount significance for its survival within the host. ...

Epidermoid cysts (EC), is one of the common benign tumours presenting anywhere in body. However penile EC rare, even rarer pediatric age group. There are usually congenital. result from proliferation epidermal cells within a circumscribed space dermis. A five-year-old boy presented with an asymptomatic, elastic swelling on ventral surface penis near corona for three years. The was flesh-colored...

NBU1 is an integrated 10.3-kbp Bacteroides element, which can excise and transfer to Bacteroides or Escherichia coli recipients, where it integrates into the recipient genome. NBU1 relies on large, >60-kbp, conjugative transposons for factors that trigger excision and for mobilization of the circular form to recipients. Previously, we showed that a single integrase gene, intN1, was necessary an...

Background: Benign and high-risk breast lesions can be excised when symptomatic or for diagnotisc purposes. Although vacuum assisted excision (VAE) is a safe effective alternative to surgical excision(SE), most hospitals still use SE the management of benign high risk lesions. To evaluate health care benefit VAE, hospital costs cosmetic outcome after VAE were compared SE. Additionally, periods ...

Various sequences within Tag1, the endogenous transposon of Arabidopsis, were examined to determine how Tag1 excision and expression are regulated. The 5' intron for the major 2.3-kb Tag1 transcript was found to be critical for the accumulation of Tag1 transcripts and for high rates of somatic excision. This was true for the autonomous element in cauliflower mosaic virus 35S-Tag1-beta-glucuroni...

Lateral talar process fragment excision may be followed by hindfoot instability and altered biomechanics. There is controversy regarding the ideal fragment size for internal fixation versus excision and a concern that excision of a large fragment may lead to significant instability. The aim of this study was to assess the effect of a simulated large lateral talar process excision on ankle and s...

BACKGROUND The standard of care for full-thickness burns is tangential excision followed by skin autografting; however, the timing of excision and grafting is subject to debate. The authors compared early (2 days) versus delayed (14 days) excision and grafting in a porcine full-thickness burn model. METHODS Full-thickness burns (n = 12) were created on the backs of two anesthetized pigs and a...

The nucleotide excision repair of certain bulky DNA lesions is abrogated in some specific non-canonical DNA base sequence contexts, while the removal of the same lesions by the nucleotide excision repair mechanism is efficient in duplexes in which all base pairs are complementary. Here we show that the nucleotide excision repair activity in human cell extracts is moderate-to-high in the case of...