Background Vitiligo is a skin disorder that affects 1% to 2% of the world population, independently of ethnicity. It presents with white plaques and skin discoloration. The presence of antibodies against melanocytes confirms the autoimmune phenomena in this disease. Regarding cellular imune response in active vitiligo, it seems to be an imbalance between T cell CD8+ and CD4+, and, moreover, an ...

Vitiligo is a common skin disease, but its pathogenesis has not been fully determined, though an autoimmune etiology is considered likely. Kawasaki disease (KD) is an acute multisystem vasculitis of childhood associated with coronary arteriopathy, and is diagnosed based on clinical criteria. Furthermore, vitiligo has been associated with several other diseases, but no report has been issued abo...

Vitiligo is an autoimmune condition characterized by loss of epidermal melanocytes. Using tetrameric complexes of human histocompatibility leukocyte antigen (HLA) class I to identify antigen-specific T cells ex vivo, we observed high frequencies of circulating MelanA-specific, A*0201-restricted cytotoxic T lymphocytes (A2-MelanA tetramer+ CTLs) in seven of nine HLA-A*0201-positive individuals w...

There is evidence in the literature about more frequent association of vitiligo with autoimmune endocrine diseases (AEDs) compared to general population. No full-fledged studies aimed at assessing prevalence AEDs Russian cohort adult patients have been conducted. The study was assess patients. Patients monitored two clinics, Endocrinology Research Centre (Clinic 1; n = 39) and Moscow Scientific...

Vitiligo, is a skin disorder, in which the loses its pigment due to loss of melanocytes. The exact cause still under research but disorder linked autoimmune disease, oxidative stress, genetics and environmental variables. disease being progressive nature often spreads all over body. Globally, Vitiligo affects nearly about 0.5% 1% people. In 2012, most recent approved classification for was give...

An Bras Dermatol. 2005;80(6):633-7. Abstract: Vitiligo is a relatively common dermatologic finding and one that has been observed since ancient times. Depigmentation of the skin, with loss of melanocytes on histology characterizes this disorder. A range of clinical phenotypes lead to varying degrees of morbidity. The cause of vitiligo remains unknown, although an autoimmune pathogenesis seems m...

BACKGROUND Vitiligo is a chronic depigmented skin disorder with regional melanocytes depletion. The pathogenesis was not completely clarified. Recently, more and more evidence suggested that polymorphisms of some genes are associated with vitiligo risk. Here, we want to examine the association between the inducible nitric oxide synthase (iNOS) gene polymorphisms and the risk of vitiligo in Chin...