Fibrosis is characterized by excessive accumulation of collagen and other extracellular matrix (ECM) components, and this process has been likened to aberrant wound healing. The early phases of wound healing involve the formation of a provisional ECM containing fibrin, fibrinogen, and fibronectin. Fibroblasts occupy this matrix and proliferate in response to activators elaborated by leukocytes ...

Mechanochemically Synergistic Treatment In article 2300103 by Xiaocong He, Hui Guo, Feng Xu, and co-workers, a combination therapy strategy based on extracellular matrix (ECM) modulator tumor microenvironment (TME)-responsive drug is developed for the first attempt of mechanochemically synergistic treatment breast cancer. ECM modulation can enhance smart diffusion to cells, while following cont...

objective: a study of the histological events under interleukin-1α (il-lα) induction of bovine nasal cartilage (bnc) could result in useful data to better understand the mechanisms involved in tissue breakdown in joint diseases. the aim of this study was to investigate the effects of il-lα on chondrocyte phenotype and extracellular matrix (ecm) changes in bnc explants. materials and methods: in...

Interactions between cells and their surrounding extracellular matrix (ECM) play a critical role in regulating cell function [1-2]. Recent studies have primarily focused on mechanotransduction by cells to sense and respond to matrix rigidity. Through these studies, it becomes clear that mechanotransduction is likely mediated by the complex interplay between the mechanosensitive focal adhesion (...

Tumor cell invasion through the stromal extracellular matrix (ECM) is a key feature of cancer metastasis, and understanding the cellular mechanisms of invasive migration is critical to the development of effective diagnostic and therapeutic strategies. Since cancer cell migration is highly adaptable to physiochemical properties of the ECM, it is critical to define these migration mechanisms in ...

Biologic scaffold materials composed of extracellular matrix (ECM) have been used in a variety of surgical and tissue engineering/regenerative medicine applications and are associated with favorable constructive remodeling properties including angiogenesis, stem cell recruitment, and modulation of macrophage phenotype toward an anti-inflammatory effector cell type. However, the mechanisms by wh...

Degradation of the extracellular matrix (ECM) is a critical step of tumor cell invasion and requires protease-dependent proteolysis focalized at the invadopodia where the proteolysis of the ECM occurs. Most of the extracellular proteases belong to serine- or metallo-proteases and the invadopodia is where protease activity is regulated. While recent data looking at global protease activity in th...

results there were 39 cases with lymph node metastasis in 59 malignant tumors, and 0 cases in 6 benign follicular type tumors. the staining scores by jt-95 of the 39 tumors with lymph node metastasis were 5+ in eight cases and 6+ in 31 cases. on the other hand, the scores of 20 malignant tumors without lymph node metastasis were < 4+ in all of the cases. in the co-cultured assay, numerous adhes...

Trophoblast invasion of the uterine extracellular matrix, a critical process for human implantation and uteroplacental vascular development, is a striking example of controlled invasiveness. To examine cellular behavior relevant to this process, human trophoblasts were cultured on (i) Millicell filters prelayered with Matrigel and (ii) coverslips precoated with a gentle slope of Matrigel (Matri...