neuroleptic malignant syndrome (nms) is a rare but life-threatening idiosyncratic side effect resulting from neuroleptic drugs. nms mainly occurs in patients treated with high-potency typical antipsychotics, but rarely caused by atypical antipsychotics. although nms is less common with atypical antipsychotic, but it seems that its incidence is rising due to increased administration of such drug...

Acamprosate reduces the craving for alcohol by decreasing glutamate activity and increasing gamma-aminobutyric acid (GABA) action in patients with alcohol dependence. Acamprosate has tolerable side effects that include diarrhea, headache, dizziness and pruritus. In this study, we report acamprosate-induced extrapyramidal symptoms in an elderly patient with no history of neurologic disease. Seve...

Background: Organophosphorus compound ingestion is one of the most common modes of deliberate self-harm in developing countries like India. Neurological complications are known in acute, intermediate and delayed phases following organophosphate poisoning. However, extrapyramidal manifestations are rarely reported. Case presentation: A 30-year-old male patient was brought...

Non-epileptic paroxysmal movement disorders are rare extrapyramidal diseases. The clinical signs are often excluded from differential diagnosis due to their paucity on clinical examination and low prevalence. The paroxysmal, stereotypical nature of non-epileptic paroxysmal movement disorders, as well as the potential response to benzodiazepines, renders these disorders susceptible to misdiagnos...

BACKGROUND Sophisticated and expensive biomarkers are proposed for the diagnostic of Alzheimer's disease (AD). The amyloid process seems to be early in AD, and brain amyloid load affects the frontal lobe. OBJECTIVE To determine if certain simple clinical signs, especially frontal-related signs, could help reach an earlier and better diagnosis. METHODS In the frame of the 3-City cohort, we c...

THIS paper records the occurrence in a 33-year-old idiot of bilateral etat marbre of caudate nucleus, putamen, and thalamus, together with a small atrophic cerebellum, atrophied inferior olives, and sclerosis of the nuclei pontis and the transverse pontine fibres. This combination of lesions is surprising since etat marbre of the corpus striatum is in the large majority of cases a phenomenon of...

Antipsychotic-induced extrapyramidal adverse effects are well recognized in the context of first-generation antipsychotic drugs. However, the introduction of second-generation antipsychotics, with atypical mechanism of action, especially lower dopamine receptors affinity, was met with great expectations among clinicians regarding their potentially lower propensity to cause extrapyramidal syndro...