the aim of this study was to evaluate the efficacy of a hyaluronic acid containing eye drop in ameliorating ocular surface pathology and discomfort in canine keratoconjunctivitis sicca (kcs). twenty five dogs with kcs treated with a topical carbomer (ca)-based tear replacement gel were moved to treatment with a hyaluronic acid (ha)-containing tear replacement eye drop. dogs were subject to a fu...

Pharmaceutical approaches based on nanotechnologies and the development of eye drops composed of the mucoadhesive polymers chitosan and hyaluronic acid are emerging strategies for the efficient treatment of ocular diseases. These innovative nanoparticulate systems aim to increase drugs' bioavailability at the ocular surface. For the successful development of these systems, the evaluation of muc...

PURPOSE Studies on drugs selected to target myopia development often use the vehicle-treated fellow eye as a control. However, it is not clear how much of the drug reaches the fellow eye, rendering it a potentially invalid control. Therefore, in this study, pupil responses were used to probe the effects of atropine in both eyes in mice, after unilateral topical application. In a second experime...

PURPOSE To determine whether prior instillation of amethocaine would increase the rate and magnitude of tropicamide-induced pupillary dilatation in darkly pigmented irides. METHOD A total of 50 healthy Africans aged 18-40 years, with darkly pigmented irides, received a drop of amethocaine in one eye and a drop of placebo in the contralateral eye, followed by two drops of tropicamide in both e...

INTRODUCTION Glaucoma patients frequently exhibit ocular surface side effects during treatment with prostaglandin eye drops. The present work investigated whether glaucoma patients suffering from signs and symptoms of ocular surface disease while using preserved latanoprost eye drops benefited from switching to preservative-free tafluprost eye drops. PATIENTS AND METHODS The analysis was base...

Methods.--The injection of rabbits with Pneumococcus or its derivatives was carried out as described in a previous communication (1). Eye Test.--Eye tests were done according to the technique described by Derick and Swift (3, 4). The cornea was anesthetized with one drop of 10 per cent novocaine, and then it was lightly scarified with a cataract knife. Three scratches were made on one of the up...