Due to their prevalence and roles in biological systems, single mismatches adjacent to G-U pairs are important RNA structural elements. Since there are only limited experimental values for the stability of single mismatches adjacent to G-U pairs, current algorithms using free energy minimization to predict RNA secondary structure from sequence assign predicted thermodynamic values to these type...

The Saccharomyces cerevisiae homologs of the bacterial mismatch repair proteins MutS and MutL correct replication errors and prevent recombination between homeologous (nonidentical) sequences. Previously, we demonstrated that Msh2p, Msh3p, and Pms1p regulate recombination between 91% identical inverted repeats, and here use the same substrates to show that Mlh1p and Msh6p have important antirec...

Bandpass sampling (BPS) is a widely used technique where one samples a bandpass-filtered signal at a sampling rate below its Nyquist rate (twice the upper cutoff frequency). For a BPS time-interleaved ADC (TIADC), its dynamic range is subject to the frequency-dependent mismatches generally introduced by the differences of process, supply voltage and temperature between constituent ADCs. This pa...

The identification of permissible HLA class II mismatches can prevent DSA in mismatched transplantation. The HLA-DR phenotype of recipients contributes to DSA formation by presenting allo-HLA-derived peptides to T-helper cells, which induces the differentiation of B cells into plasma cells. Comparing the binding affinity of self and nonself allo-HLA-derived peptides for recipients' HLA class II...

Modern signal processing applications emerging in telecommunication and instrumentation industries need high-speed analog-to-digital converters (ADCs), which can be achieved by employing a time-interleaved parallel array of ADCs (time-interleaved ADCs). The time interleaving of the channels allows to increase the sampling rate by the number of channels compared to a single channel. Unfortunatel...