Background Fatigue is a frequent, disabling issue in systemic lupus erythematosus (SLE). It is, however, difficult to quantify. The Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue Scale has been validated SLE and successfully used assess fatigue. Objectives To evaluate the application influence factors (FACIT-Fatigue) scale patients with (SLE) Methods 1061 pts who fulfilled SLI...

BACKGROUND Sarilumab is a human monoclonal antibody directed against the alpha subunit of the interleukin-6 receptor complex. In the MOBILITY phase III randomized controlled trial (RCT), sarilumab + methotrexate (MTX) treatment resulted in clinical improvements at 24 weeks that were maintained at 52 weeks in adults with rheumatoid arthritis (RA), who have inadequate response to MTX (MTX-IR). Th...

CONTEXT Arthralgia is common and debilitating for a significant proportion of breast cancer survivors (BCSs) and leads to poor adherence to aromatase inhibitors (AIs). Despite increased recognition of the negative impact of arthralgia on function and the poor adherence that results, very few interventions have been developed to target this side effect. OBJECTIVE This study aimed to determine ...

The FACIT-SME European FP-7 project targets to facilitate the use and sharing of Software Engineering (SE) methods and best practices among software developing SMEs. In this context, we present an automatic semantic document searching method based on Word Sense Disambiguation which exploits both syntactic and semantic information provided by external dictionaries and is easily applicable for an...

I have been astonished how rarely an organ can be named, towards which no transitional grade is known to lead. The truth of this remark is indeed shown by that old canon in natural history of Natura non facit saltum. We meet with this admission in the writings of almost every experienced naturalist; or, as Milne Edwards has well expressed it, nature is prodigal in variety, but niggard in innova...

The relativistic transformation equations for mass, momentum and energy are derived without using conservation laws but based on the idea that nature ensures a smooth transition from the physical properties of a tardyon to those of a photon.

Abstract Background Upadacitinib (UPA) demonstrated efficacy and safety in the phase 3 U-EXCEED (NCT03345836) U-EXCEL (NCT03345849) induction, U-ENDURE (NCT03345823) maintenance trials patients (pts) with moderately to severely active Crohn’s disease (CD). We evaluated impact of UPA on health-related quality life (QoL) pts CD. Methods Clinical responders 45 mg (UPA45) induction were re-randomis...