نتایج جستجو برای: factor eight inhibitor bypassing activity
تعداد نتایج: 2125544 فیلتر نتایج به سال:
Two patients with hemophilia A complicated with high-titer alloantibodies have been treated by repeated infusions of microgram quantities of pure human Factor VIIa. Patient 1 was presented with a gastrocnemius muscle bleeding that involved the knee joint. Upon treatment with Factor VIIa the circumference of the muscle decreased and joint mobility increased substantially. Patient 2 was given Fac...
Background: Hemophilia B is a bleeding disorder with a recessive X-linked inheritance pattern, in which the infected individuals have low levels of factor IX in their plasma. Affected individuals may have bleeding episodes after trauma or spontaneously considering the plasma level of factor IX. In order to prevent these episodes and to control bleeding, they should use coagulation factor concen...
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. " Our poor family seems persecuted by this awful disease, the worst I know. " Queen Victoria (1819–1901) of the United Kingdom of Great Britain and Ireland wrote in her diary. She is well known as the most famous carrier of hemophilia, the " royal disease " ...
Plasma or serum extrinsic pathway inhibitor (EPI) activity was measured in 24 patients with disseminated intravascular coagulation (DIC) and in 23 patients with severe hepatocellular disease. EPI was measured as activity in a test sample that inhibited factor VIIa/tissue factor (TF)-catalyzed activation of 3H-factor IX (activation peptide release) in the presence of factor X. Of the 24 patients...
Acquired haemophilia A (AHA) is caused by autoantibody inhibitors of coagulation factor VIII (FVIII : C). Recent onset of bleeds and isolated prolongation of the activated partial thromboplastin time (aPTT) are characteristic features of the disorder. Reduced FVIII : C activity and a detectable FVIII : C inhibitor in the Bethesda assay confirm the diagnosis. Patients should be referred to exper...
development of inhibitor to factor viii is the most serious complication of hemophilia therapy. to determine the prevalence of inhibitors in iran hemophilia a patients exposed to blood products, 1280 hemophilia a patients (age range 9 months-84 years) were evaluated. all patients received several blood products such as fresh frozen plasma (ffp), cryoprecipitate, and factor viii. 635 of 1280 pat...
The novel Bruton's tyrosine kinase inhibitor ibrutinib has demonstrated high response rates in B-cell lymphomas; however, a growing number of ibrutinib-treated patients relapse with resistance and fulminant progression. Using chemical proteomics and an organotypic cell-based drug screening assay, we determine the functional role of the tumour microenvironment (TME) in ibrutinib activity and acq...
Cyclin-dependent kinases (Cdks) are essential for the control of cell cycle transitions, and changes in activity of a single Cdk1-cyclin B complex can order the cell cycle in fission yeast. Using mathematical modelling and experiments in Xenopus egg extracts, we have shown that it is not Cdk1 activity per se , that determines the cell cycle, but the ratio of activities of Cdk1 and the Cdk1-coun...
The existing solutions for counteracting and preventing the interception of data tokens two-factor authentication are considered. Features that may indicate presence a silent reverse proxy server chosen. It is proposed to analyze information about additional time anomalies, which usually created by server. advantage this approach characteristics generated on client-side, malicious cannot modify...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید