heart failure is common in patients with chronic renal disease, either as a complication of renal failure or from shared risk factors, or is the major cause of death in patients on dialysis. at present, end stage renal disease (esrd) patients who have systolic heart failure are considered high-risk for surgery; and nephrologists and cardiologists are reluctant to refer these patients for kidney...

comments on related versions. Abstract We provide a general model for comparing stepwise and lumpy investments, considering stage specific volatilities, drifts and possibility of project failure. Stepwise investments allow for interim project value realizations, instead of considering only a final project value as in sequential investments. We conceive of an environment in which stepwise invest...

Operational failures in centrifuge pumps could be hydraulic or mechanical. However, most of these mechanical and hydraulic failures are connected cause of their operational nature and finding the right cause is due to considering numerous mechanical and hydraulic signs and parameters in pumps. On the other hand, due to non-linear and fluctuant behavior of pumps in the matter of time and not pre...

BACKGROUND AND OBJECTIVE Insulin degludec is a basal insulin with a slow and distinct absorption mechanism resulting in an ultra-long, flat, and stable pharmacokinetic profile in patients with diabetes mellitus. The aim of this study was to examine the effect of hepatic impairment on the single-dose pharmacokinetics of insulin degludec. METHODS Twenty-four subjects, allocated to one of four g...

Effects of many medical procedures appear after a time lag, when a significant change occurs in subjects’ failure rate. This paper focuses on the detection and estimation of such changes which is important for the evaluation and comparison of treatments and prediction of their effects. Unlike the classical change-point model, measurements may still be identically distributed, and the change poi...

Modern society critically depends on the services electric power provides. Power systems rely on a network of power lines and transformers to deliver power from sources of power (generators) to the consumers (loads). However, when power lines fail (for example, through lightning or natural disasters) or when the system is heavily used, the network is often unable to fulfill all of the demand fo...

progressive collapse is defined as the spread of an initial failure from element to element, eventually resulting in the collapse of an entire structure or a disproportionately large part of it. the current progressive collapse analyses and design methods in guidelines and codes focus on the alternate load path method. this method is suitable especially in the case of blast-induced progressive ...

x-100 steel is one of the most recently developed materials for production of gas transportation pipelines. this material is severely anisotropic. smooth and notched round bars with different notch radius and flat notched specimens with different notch radius and notch depth in tension are tested to characterize the failure of this material under quasi-static loading condition. triaxiality fact...

In this paper, a reliability approach on reconfiguration decisions in a supply chain network is studied based on coupling the simulation concepts and artificial neural network. In other words, due to the limited budget for warehouse relocation in a supply chain, the failure probability is assessed for determining the robust decision for future supply chain configuration. Traditional solving ...