Heart failure remains a major public-health problem with an increase in the number of patients worsening from this disease. Despite current medical therapy, the condition still has a poor prognosis. Heart failure is complex but mitochondrial dysfunction seems to be an important target to improve cardiac function directly. Our goal was to analyze the effects of MitoQ (100 µM in drinking water) o...

Congestive heart failure, in particular with preserved left ventricular ejection fraction, is increasing in incidence. Hypertensive disease is also increasing, and data suggest that this is a major contributor to the increasing incidence of congestive heart failure. In addition, there are data suggesting that patients with hypertension not only have a high prevalence of impaired left ventricula...

But what do we do when one number is at goal and the other is not? It is clear that in individuals younger than 50 years, diastolic BP (DBP) is the better predictor of future complications of hypertension, whereas in those 50 years and older, systolic BP (SBP) is a better predictor of future complication risk. Most individuals with hypertension are 50 years or older, and for these patients, SBP...

Using finite element nonlinear analysis, the dynamic soil pressure on perimeter retainingwalls of structures is investigated. Nonlinear Drucker Prager failure criterion is used to model the soilbehavior in the near field. The far field soil and the middle structure are assumed to behave as linearelastic materials. The soil-wall interface behavior is modeled incorporating nonlinear interfaceelem...

Level I evidence shows that continuous positive airway pressure (CPAP) and bilevel positive airway pressure (BiPAP) are effective for preventing intubation and saving the lives of carefully selected patients with acute respiratory failure. This ar ticle attempts to review this evidence. We began by searching the literature, using OVID, looking for all randomized studies of congestive heart fail...

The development of encephalopathy in patients with acute liver injury defines the occurrence of liver failure. The encephalopathy of acute liver failure is characterized by brain edema which manifests clinically as increased intracranial pressure. Despite the best available medical therapies a significant proportion of patients with acute liver failure die due to brain herniation. The present r...

This study numerically predicts the failure scenario of a cracked concrete gravity dam through a push-over nonlinear analysis. The mixed-mode Linear Elastic Fracture Mechanics (LEFM) was employed using the extended finite element method (XFEM). The dam base was considered to be fully fixed without any foundation effects. The hydrostatic pressure on the dam's upstream face was increased incremen...

objective neuromuscular disorders (diseases of the motor unit), can cause respiratory problems such as impaired cough reflex, chest deformity, recurrent pneumonia and acute respiratory failure; these are the worst most common complications of these diseases and the leading cause of death in such patients (1, 2). their management hence, very often, entails admission to the pediatric intensive ca...