نتایج جستجو برای: familial history
تعداد نتایج: 402168 فیلتر نتایج به سال:
We report a case of spontaneous familial pneumothorax in fraternal twin boys. The twins' family history is remarkable for reactive airway disease and a female sibling also born with spontaneous pneumothorax. The family had no history of connective tissue disorders, renal cancer, or dermatologic diseases. Analysis of the twins' α(1)-antitrypsin (AAT) genotype, phenotype, and serum concentration ...
OBJECTIVE To determine whether the G-to-A substitution at nucleotide 209 (G209A) mutation in the alpha-synuclein gene is responsible for familial Parkinson disease (PD) in the US population. DESIGN Polymerase chain reaction-based DNA analysis of consecutive patients with PD and family history of PD. SETTING A university-affiliated movement disorder clinic and a Veterans Affairs clinical res...
The association between a familial history of autoimmune disease and childhood acute leukemia was investigated in a French case-control study that, overall, was designed to assess the role of perinatal, infectious, environmental, and genetic factors in the etiology of childhood acute leukemia. Familial histories of autoimmune disease in first- and second-degree relatives were compared in 279 in...
BACKGROUND Abnormalities in the connectivity of white-matter (WM) tracts in schizophrenia are supported by evidence from post-mortem investigations, functional and structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). The aims of this study were to explore the microstructural changes in first-episode schizophrenia in a Han Chinese population and to investigate whether ...
Objective. To describe a unique case of familial Bell's palsy and summarize the current literature regarding possible hereditary influences. Design. Case report. Main Outcome Measures. Clinical exam, CSF analysis, and family history provided per the patient. Results. We report the case of a 58-year-old female who presented with recurrent and bilateral episodes of facial palsy. The patient under...
BACKGROUND Family studies provide a useful approach to exploring the continuities and discontinuities between major depressive disorder (MDD) in children and adolescents and MDD in adults. We report a family study of MDD in a large community sample of adolescents. METHODS Probands included 268 adolescents with a history of MDD, 110 adolescents with a history of nonmood disorders but no histor...
Background: Environmental exposures in early life have been implicated in the aetiology of inflammatory bowel disease. Objective: To examine environmental risk factors prior to the development of inflammatory bowel disease in a paediatric population based case control study. Methods: A total of 222 incident cases of Crohn’s disease and 60 incident cases of ulcerative colitis occurring before 17...
Five patients, two British and three French, with late onset amyloid neuropathy were found to have mutations of the transthyretin (TTR) gene associated with the Portuguese and German types of familial amyloid polyneuropathy. Familial amyloid polyneuropathy is rare in the United Kingdom and has not previously been defined at a molecular genetic level. None of the patients had a history of affect...
Introduction: Hearing impairment has a large economic and social burden on societies. Determination of related demographic and audiologic characteristics of deaf patients can help to understand the related factors to hearing impairment and prevent it. In this study we assessed the demographic and audiologic characteristics of deaf patients in a population in the north of Iran. Materials and Met...
Background : After lung cancer, breast cancer is the second cause of mortality among women. Although the prevalence of this disease has been increased, but the rate of mortality has not been changed during last three decades, this may be due to early diagnosis at the first stage of disease . Objective : To determine risk factors of breast cancer in women. Design : It was a case- control s...
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