Acylation-stimulating protein (ASP) is a small, basic, human plasma protein that markedly stimulates triglyceride synthesis in human adipocytes and cultured human skin fibroblasts. The present studies examine the response to ASP of cultured skin fibroblasts from normal subjects patients with hyperapobetalipoproteinemia, patients with familial hypercholesterolemia, and patients with hypertriglyc...

Cardiovascular diseases are the leading cause of disability and mortality worldwide. rate is steadily increasing despite large-scale preventive measures. Familial hypercholesterolemia most common genetically determined disorder lipid metabolism as major blood circulatory system development progression. Worldwide, there 6.8–8.5 million children with this primary dyslipidemia. Early (in childhood...

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