IMPORTANCE The risk of next melanoma in patients with 2 or more previous melanomas stratified by familial and sporadic cases separately has not yet been reported, although a few population-based studies have assessed the risk of second melanoma. OBJECTIVE To assess the risk of next melanoma in patients with multiple primary melanomas by number of previous melanomas, stratified by demographic ...

Most guidelines developedfor cancers screening and for cardiovascular risk management use rules to estimate familial risk. These rules are complex, dificult to memorize, and need to collect a complete pedigree. This paper describes a generic computerized method to estimate familial risks and its implementation in an internet-based application. The program is based on 3 generic models: a model o...

Polycystic kidney disease is a multisystemic familial inherited disease. A symptomatic treatment approach the standard modality for autosomal dominant polycystic (ADPKD) complications and life-long 50% chronic renal failure risk, as transplantation only definitive treatment.

The Swedish Family-Cancer Database has been used for some 10 years in the study of familial risks at all common sites. In the present paper we describe some of the main features of version VII of this Database, assembled in year 2006. This update included all residents in Sweden born or immigrated in 1932 and later (offspring) with their biological parents, a total of 11.5 million individuals. ...

conclusions although the frequency of hbsag seropositivity in the present study was close to that observed in the overall iranian population, the seroprevalence of anti-hbc was higher, possibly due to the exposure of the elderly to more risk factors. the risk factors were similar. these included a history of blood transfusions, cupping, hospital admission, endoscopy, or familial hbv/hcv infecti...

The reasons for the high risk of contralateral breast cancer are not understood, although polygenic mechanisms have been suggested to be involved. The nationwide Swedish Family-Cancer Database was used to examine the interaction of the risks for contralateral and familial cancer. Relative risks were separately determined for contralateral and familial breast cancers, and these were tested for a...