study of a family with autosomal dominant polycystic kidney diseases (adpkd) in five generations, including 96 healthy and 47 affected individuals, has been carried out in tehran. investigation on individuals, including final diagnoses by clinical findings, sonography, radiography and laboratory results, have lead to the completion of genealogical chart of the family. the affected individuals h...

marfan’s syndrome (mfs) is a genetic disorder associated with autosomal dominant inheritance. in mfs, the most prevalent cause of death is cardiovascular involvement. here we introduce a family with a severe penetration of mfs. eleven members of this family have mfs (father, two daughters, three sons, and five grandchildren). the most common cardiac involvement in our patients was mitral valve ...

  When patients are at high risk of dying, their families experience burdens such as decision making on treatment choices and concern about the patient's condition that can cause the families' psychological symptoms. The aim of this study was to assess the main psychological reaction of the patients' family members in intensive care units. This analytical study was conducted by using Depression...

Cadherins comprise a family of calcium-dependent cell adhesion molecules that regulate many basic developmental processes and are fundamental for the maintenance of both embryonic and adult tissue structure (reviewed in Yap et al., 1997; Stappert and Kemler, 1999). The most studied member of the cadherin protein family is E-cadherin, a transmembrane adhesion protein localized in the adherens ju...

The Unified Modeling Language is extensible, and so can be regarded as a family of languages. Implicitly or explicitly, any particular UML model should be accompanied by a definition of the particular UML family member used for the model. The definition should cover syntactic and semantic issues. This paper proposes a mechanism for associating models with such definitions. Any particular defini...

Dahlback in 1993 and Bertina in 1994 made the landmark discovery that resistance to activated protein C due to a point mutation in the factor V gene (G1691A in exon 10, leading to Arg506Gln) is associated with a 6to 8-fold increased risk of venous thrombosis.1,2 The importance of these findings, which have since been confirmed and cited more than 2000 times in the medical literature, is due to ...

Angiomotin (Amot) family contains three members: Amot (p80 and p130 isoforms), Amot-like protein 1 (Amotl1), and Amot-like protein 2 (Amotl2). Amot proteins play an important role in tube formation and migration of endothelial cells and the regulation of tight junctions, polarity, and epithelial-mesenchymal transition in epithelial cells. Moreover, these proteins regulate the proliferation and ...

How is it diagnosed? If you have an older family member who may have depression, it is important for him or her to see a doctor. The doctor will ask about symptoms of depression. The doctor also may ask the patient to fill out a survey. The score on the survey can show whether your family member has depression. Are there other conditions that can look like depression? Other conditions, such as ...