نتایج جستجو برای: feeder cells
تعداد نتایج: 1387280 فیلتر نتایج به سال:
Human embryonic stem cells (hESCs) are pluripotent cells that have indefinite replicative potential and the ability to differentiate into derivatives of all three germ layers. hESCs are conventionally grown on mitotically inactivated mouse embryonic fibroblasts (MEFs) or feeder cells of human origin. In addition, feeder-free culture systems can be used to support hESCs, in which the adhesive su...
STAT3 belongs to the signal transducers and activators of transcription (STAT) family. Activation of STAT3 via the LIF receptor/ gp130 signaling complex allows the derivation and propagation of embryonic stem (ES) cells from mouse blastocysts in the presence of feeders. Intriguingly, ES cells have not been established from some strains of mice, and not at all from rats under the LIF/feeder cond...
BACKGROUND Feeder cells are frequently used for the early-stage of derivation and culture of human embryonic stem cell (hESC) lines. METHODS We established a conditionally immortalized human foreskin fibroblast line that secreted basic fibroblast growth factor (bFGF). These cells were used as feeder cells for hESC culture and induced pluripotent stem (iPS) cell derivation and expansion. This ...
STAT3 belongs to the signal transducers and activators of transcription (STAT) family. Activation of STAT3 via the LIF receptor/ gp130 signaling complex allows the derivation and propagation of embryonic stem (ES) cells from mouse blastocysts in the presence of feeders. Intriguingly, ES cells have not been established from some strains of mice, and not at all from rats under the LIF/feeder cond...
objective(s): ex vivo expansion of hematopoitic stem cells is an alternative way to increase umbilical cord blood (ucb)-cd34+ cells for bone marrow transplantation. for this purpose demineralized bone matrix (dbm) and mineralized bone allograft (mba) as two scaffolds based on bone matrix and stem cell niche, were simultaneously used to enhance the effect of human mesenchymal progenitor cells (m...
Background: Keratinocyte stem cell is one of the adult stem cells that inhabits the skin and contributes to skin function and renewal. Adult stem cells are best defined by their capacity to self-renew, and to maintain tissue function for a long period of time. These findings indicate the importance of these cells for clinical applications including regenerative medicine, tissue engineering and ...
Background The promise of pluripotent stem cells lies in their ability to form any cell or tissue in the body. However, this promise requires a stable and reproducible method to grow the cells. Current methods rely on feeder cells or extracellular matrix proteins to cover the cultureware growth surface, and either manual selection or enzymatic dissociation in cell passaging and harvesting. This...
Human embryonic stem cell (hESC) lines, after directed differentiation, hold the greatest potential for cell transplantation treatment in many severe diseases. Good manufacturing practice (GMP) quality, defined by both the European Medicines Agency and the Food and Drug Administration, is a requirement for clinical-grade cells, offering optimal defined quality and safety in cell transplantation...
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