The development of meningococcal serogroup B vaccines has been a worldwide public health priority based on continuing disease burden, combined with the scientific challenges associated with antigen identification. A new multicomponent vaccine, 4CMenB, is currently being evaluated for global licensure. The multicomponent strategy accounts for multiple surface antigens and, therefore, provides va...

A native outer membrane vesicles (NOMV) vaccine was developed from three antigenically diverse strains of Neisseria meningitidis that express the L1,8, L2, and L3,7 lipooligosaccharide (LOS) immunotypes, and whose synX, and lpxL1 genes were deleted.. Immunogenicity studies in mice showed that the vaccine induced bactericidal antibody against serogroups B, C, W, Y and X N. meningitidis strains. ...