Multiple linear regression modelling is used to analyse in situ Raman spectra recorded during a “CO-free” Pauson–Khand type cyclisation which enables knowledge-driven optimisation protocol.

the backwardness of the countryside is most important issues of developing countries. the result of this study, based on descriptive - analysis studies, shows that revive traditional arts and crafts with much charm with planning and organizing on development stimulus projects, can direct influence on the villager’s empowerment. of course, the existence of such attractions, itself, without provi...

Palladium(II)-catalysed cycloalkenylation (Saegusa-Ito cyclisation) has been used for the first time to transform difluorinated silylenol ethers to difluorinated cycloalkenones under mild conditions. The silylenol ether precursors were prepared in two high-yielding steps from trifluoroethanol, and cyclised in moderate to good yields. A combination of air and copper(I) chloride in acetonitrile g...

Metallaphotoredox catalysis for furan synthesis: The cyclisation of yne-enones proceeds smoothly via consecutive reductive radical-polar crossover and cycloisomerization processes enabled by cooperative photoredox-neutral copper catalysis.

A new method for the synthesis of cystathionine containing cyclic peptides has been developed. Conventionally such systems are typically made with relatively late-stage on-resin cyclisation involving reaction between a chlorohomoalanine and cysteine residue. We offer a different approach involving early incorporation of a cystathionine residue through on-resin reaction between a cysteine residu...

Traditionally, the notion of home crafting connotes the use of alow-techo materials and techniques; but increasingly, the once-distinct worlds of crafting and computational media have become integrated, to the mutual bene®t of both cultures. In this paper, we discuss a wide range of recurring issues in the integration of crafts and computation, drawing upon a variety of related research project...